Expression of proliferation markers Ki67, cyclin a, geminin and aurora-kinase a in primary breast carcinomas and corresponding distant metastases

A. Tőkés, A. Szász, Franciska Geszti, Lilla V. Lukács, I. Kenessey, Eszter Turányi, Nóra Meggyesházi, István A. Molnár, János Fillinger, Ibolya Soltész, Katalin Bálint, Z. Hanzély, Gabriella Arató, M. Szendrői, J. Kulka

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Aims: To assess the expression of the following cell cycle regulatory proteins in primary metastatic breast carcinomas (MBCs) and on availability in matched distant metastases (DMs): Ki67, cyclin A, geminin and aurora-kinase A (aurkA); and to compare the expression of these markers in early MBC (EMBC) and late MBC separated into groups according to median time point on metastatic event occurred (28 months). Methods: The expression of the above mentioned markers was analysed in a total of 47 primary MBCs and 59 DMs (out of which 37 were pairs) by immunohistochemistry. Fourteen breast carcinomas with no relapse over a 10-year follow-up period were utilised as control cases (CBC). Results: Among the MBCs, 22 metastasised to the bone, 4 to the lung and 21 to the central nervous system (CNS). Geminin (p

Original languageEnglish
Pages (from-to)274-282
Number of pages9
JournalJournal of Clinical Pathology
Volume68
Issue number4
DOIs
Publication statusPublished - Apr 1 2015

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Geminin
Aurora Kinases
Cyclins
Breast Neoplasms
Neoplasm Metastasis
Aurora Kinase A
Cyclin A
Cell Cycle Proteins
Central Nervous System
Immunohistochemistry
Bone and Bones
Recurrence
Lung

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medicine(all)

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Expression of proliferation markers Ki67, cyclin a, geminin and aurora-kinase a in primary breast carcinomas and corresponding distant metastases. / Tőkés, A.; Szász, A.; Geszti, Franciska; Lukács, Lilla V.; Kenessey, I.; Turányi, Eszter; Meggyesházi, Nóra; Molnár, István A.; Fillinger, János; Soltész, Ibolya; Bálint, Katalin; Hanzély, Z.; Arató, Gabriella; Szendrői, M.; Kulka, J.

In: Journal of Clinical Pathology, Vol. 68, No. 4, 01.04.2015, p. 274-282.

Research output: Contribution to journalArticle

Tőkés, A. ; Szász, A. ; Geszti, Franciska ; Lukács, Lilla V. ; Kenessey, I. ; Turányi, Eszter ; Meggyesházi, Nóra ; Molnár, István A. ; Fillinger, János ; Soltész, Ibolya ; Bálint, Katalin ; Hanzély, Z. ; Arató, Gabriella ; Szendrői, M. ; Kulka, J. / Expression of proliferation markers Ki67, cyclin a, geminin and aurora-kinase a in primary breast carcinomas and corresponding distant metastases. In: Journal of Clinical Pathology. 2015 ; Vol. 68, No. 4. pp. 274-282.
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AU - Szász, A.

AU - Geszti, Franciska

AU - Lukács, Lilla V.

AU - Kenessey, I.

AU - Turányi, Eszter

AU - Meggyesházi, Nóra

AU - Molnár, István A.

AU - Fillinger, János

AU - Soltész, Ibolya

AU - Bálint, Katalin

AU - Hanzély, Z.

AU - Arató, Gabriella

AU - Szendrői, M.

AU - Kulka, J.

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