Expression of PARK7 is increased in celiac disease

Péter Vörös, Erna Sziksz, Leonóra Himer, Anna Ónody, Domonkos Pap, Klára Frivolt, B. Szebeni, Rita Lippai, Hajnalka Gyorffy, Andrea Fekete, Ferenc Brandt, Kriszta Molnár, G. Verès, A. Arató, T. Tulassay, A. Vannay

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Recently, it has been suggested that the gene called Parkinson's disease 7 (PARK7) might be an upstream activator of hypoxia-inducible factor (HIF)-1α, which plays a major role in sustaining intestinal barrier integrity. Furthermore, PARK7 has been proposed to participate in the Toll-like receptor (TLR)-dependent regulation of the innate immune system. Our aim was to investigate the involvement of PARK7 in the pathogenesis of coeliac disease (CD). Duodenal biopsy specimens were collected from 19 children with untreated CD, five children with treated CD (maintained on gluten-free diet), and ten children with histologically normal duodenal biopsies. PARK7 mRNA expression and protein level were determined by real-time polymerase chain reaction (PCR) and Western blot, respectively. Localization of PARK7 was visualized by immunofluorescence staining. Protein level of PARK7 increased in the duodenal mucosa of children with untreated CD compared to children with treated CD or to control biopsies (p

Original languageEnglish
Pages (from-to)401-408
Number of pages8
JournalVirchows Archiv
Volume463
Issue number3
DOIs
Publication statusPublished - Sep 2013

Fingerprint

Celiac Disease
Parkinson Disease
Biopsy
Gluten-Free Diet
Hypoxia-Inducible Factor 1
Toll-Like Receptors
Fluorescent Antibody Technique
Real-Time Polymerase Chain Reaction
Immune System
Mucous Membrane
Proteins
Western Blotting
Staining and Labeling
Messenger RNA
Genes

Keywords

  • Children
  • Coeliac disease
  • Duodenal biopsies
  • PARK7/DJ1

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology
  • Molecular Biology

Cite this

Vörös, P., Sziksz, E., Himer, L., Ónody, A., Pap, D., Frivolt, K., ... Vannay, A. (2013). Expression of PARK7 is increased in celiac disease. Virchows Archiv, 463(3), 401-408. https://doi.org/10.1007/s00428-013-1443-z

Expression of PARK7 is increased in celiac disease. / Vörös, Péter; Sziksz, Erna; Himer, Leonóra; Ónody, Anna; Pap, Domonkos; Frivolt, Klára; Szebeni, B.; Lippai, Rita; Gyorffy, Hajnalka; Fekete, Andrea; Brandt, Ferenc; Molnár, Kriszta; Verès, G.; Arató, A.; Tulassay, T.; Vannay, A.

In: Virchows Archiv, Vol. 463, No. 3, 09.2013, p. 401-408.

Research output: Contribution to journalArticle

Vörös, P, Sziksz, E, Himer, L, Ónody, A, Pap, D, Frivolt, K, Szebeni, B, Lippai, R, Gyorffy, H, Fekete, A, Brandt, F, Molnár, K, Verès, G, Arató, A, Tulassay, T & Vannay, A 2013, 'Expression of PARK7 is increased in celiac disease', Virchows Archiv, vol. 463, no. 3, pp. 401-408. https://doi.org/10.1007/s00428-013-1443-z
Vörös P, Sziksz E, Himer L, Ónody A, Pap D, Frivolt K et al. Expression of PARK7 is increased in celiac disease. Virchows Archiv. 2013 Sep;463(3):401-408. https://doi.org/10.1007/s00428-013-1443-z
Vörös, Péter ; Sziksz, Erna ; Himer, Leonóra ; Ónody, Anna ; Pap, Domonkos ; Frivolt, Klára ; Szebeni, B. ; Lippai, Rita ; Gyorffy, Hajnalka ; Fekete, Andrea ; Brandt, Ferenc ; Molnár, Kriszta ; Verès, G. ; Arató, A. ; Tulassay, T. ; Vannay, A. / Expression of PARK7 is increased in celiac disease. In: Virchows Archiv. 2013 ; Vol. 463, No. 3. pp. 401-408.
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