Expression of p53 and pRb in bladder and prostate cancers of patients having both cancers

Amar Singh, Richard F. Jones, Henry Friedman, Shahendeh Hathir, Gyorgyike Soos, Andras Zabo, Gabriel P. Haas

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Abstract

Evidence has been presented that tumor suppressor genes p53 and Rb play a crucial role in the development of both human prostate and bladder cancer. Patients with either cancer are at an increased risk for developing the other malignancy as compared to the general population. The purpose of the present study was to investigate whether there is abnormal expression of these two suppressor proteins in both the bladder and prostate cancers of the same patient. The expression of p53 and pRb in bladder and prostate cancer specimens obtained from 15 patients having both cancers was studied using immunohistochemical staining with antibodies against these proteins. The expression of p53 and pRb in both bladder and prostate cancers of the same patient was congruent in 8 of 15 cases (53%) for p53 and 9 of 15 cases (60%) for pRb. The significance of these findings warrants further investigations.

Original languageEnglish
Pages (from-to)5415-5417
Number of pages3
JournalAnticancer research
Volume19
Issue number6 B
Publication statusPublished - Nov 1 1999

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Keywords

  • Bladder cancer
  • Prostate cancer
  • p53
  • pRb

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Singh, A., Jones, R. F., Friedman, H., Hathir, S., Soos, G., Zabo, A., & Haas, G. P. (1999). Expression of p53 and pRb in bladder and prostate cancers of patients having both cancers. Anticancer research, 19(6 B), 5415-5417.