Expression of OKM5 antigen on human keratinocytes in positive intracutaneous tests for delayed-type hypersensitivity

M. Simon, J. Hunyadi

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Antigenic characteristics of human keratinocytes (HK) were studied in positive intracutaneous tests for delayed-type hypersensitivity in vivo using murine monoclonal antibodies against human OKM5, OKM1, OKT6, Leu-7 and HLA-DR antigens and compared with those of negative skin reactions. By contrast to negative intracutaneous tests, keratinocytes displayed both OKM5 and HLA-DR antigens in all positive skin reactions above the dermal inflammatory infiltrate. OKM5 recognizes an 88-kilodalton cell surface determinant of monocytes, which could also be introduced in vitro in keratinocytes upon incubation with γ-interferon. We demonstrate here for the first time that the expression of this macrophage marker can also be induced in vivo in the HK.

Original languageEnglish
Pages (from-to)121-125
Number of pages5
JournalDermatologica
Volume175
Issue number3
Publication statusPublished - Jan 1 1987

ASJC Scopus subject areas

  • Dermatology

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