Expression of NFkBl, GADD45A and JNKl in salivary gland carcinomas of different histotypes

Gyula Gobel, István Szanyi, Péter Révész, Miklós Bauer, Imre Gerlinger, Árpád Németh, István Ember, Katalin Gocze, Katalin Gombos

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4 Citations (Scopus)

Abstract

The class of salivary gland tumours is very heterogenous, both in a histopathological and clinical sense. Since they are uncommon lesions, their clinical management is still problematic. Molecular mechanisms underlying the development of these cancer types may be fundamental for the diagnosis, treatment and prognosis of this disease. In this study, the gene expression of nuclear factor-kappa B (NKkBl/p65), c-Jun N-terminal kinase (JNKl) and growth arrest and DNA damage (GADD45A), which all play an important role in inflammatory and cell survival mechanisms, was assessed in benign and malignant neoplasms of the salivary gland.6 The absolute mRNA content of paraffin embedded samples of salivary gland cancer was determined by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) using specific primers for NFkBl, GADD45A and JNKl. Expression values (relative to HPRT) were statistically evaluated. Among the detected alterations in gene expression, the only difference reaching statistical significance was in the case of NFkBl in adenocystic carcinomas (p=0.05). Given the importance of these signalling mechanisms in the biology of tumorigenesis, these results may be implemented in further research and these genes might become targets for innovative diagnostic and therapeutic strategies.

Original languageEnglish
Pages (from-to)81-88
Number of pages8
JournalCancer Genomics and Proteomics
Volume10
Issue number2
Publication statusPublished - Jan 1 2013

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Keywords

  • GADD45A
  • Gene expression
  • JNKl
  • NFkB
  • Salivary gland tumours

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Gobel, G., Szanyi, I., Révész, P., Bauer, M., Gerlinger, I., Németh, Á., Ember, I., Gocze, K., & Gombos, K. (2013). Expression of NFkBl, GADD45A and JNKl in salivary gland carcinomas of different histotypes. Cancer Genomics and Proteomics, 10(2), 81-88.