Expression of myeloid-specific genes in childhood acute lymphoblastic leukemia - A cDNA array study

T. Niini, K. Vettenranta, J. Hollmén, M. L. Larramendy, Y. Aalto, H. Wikman, B. Nagy, J. K. Seppänen, A. F. Salvador, H. Mannila, U. M. Saarinen-Pihkala, S. Knuutila

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Several specific cytogenetic changes are known to be associated with childhood acute lymphoblastic leukemia (ALL), and many of them are important prognostic factors for the disease. Little is known, however, about the changes in gene expression in ALL. Recently, the development of cDNA array technology has enabled the study of expression of hundreds to thousands of genes in a single experiment. We used the cDNA array method to study the gene expression profiles of 17 children with precursor-B ALL. Normal B cells from adenoids were used as reference material. We discuss the 25 genes that were most over-expressed compared to the reference. These included four genes that are normally expressed only in the myeloid lineages of the hematopolietic cells: RNASE2, GCSFR, PRTN3 and CLC. We also detected over-expression of S100A12, expressed in nerve cells but also in myeloid cells. In addition to the myeloid-specific genes, other over-expressed genes included AML1, LCP2 and FGF6. In conclusion, our study revealed novel information about gene expression in childhood ALL. The data obtained may contribute to further studies of the pathogenesis and prognosis of childhood ALL.

Original languageEnglish
Pages (from-to)2213-2221
Number of pages9
JournalLeukemia
Volume16
Issue number11
DOIs
Publication statusPublished - Nov 1 2002

Fingerprint

Oligonucleotide Array Sequence Analysis
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Genes
Gene Expression
Adenoids
Myeloid Cells
Transcriptome
Cytogenetics
B-Lymphocytes
Technology
Neurons

Keywords

  • Acute lymphoblastic leukemia
  • cDNA array
  • Gene expression
  • Myeloid-specific genes

ASJC Scopus subject areas

  • Hematology
  • Cancer Research

Cite this

Niini, T., Vettenranta, K., Hollmén, J., Larramendy, M. L., Aalto, Y., Wikman, H., ... Knuutila, S. (2002). Expression of myeloid-specific genes in childhood acute lymphoblastic leukemia - A cDNA array study. Leukemia, 16(11), 2213-2221. https://doi.org/10.1038/sj.leu.2402685

Expression of myeloid-specific genes in childhood acute lymphoblastic leukemia - A cDNA array study. / Niini, T.; Vettenranta, K.; Hollmén, J.; Larramendy, M. L.; Aalto, Y.; Wikman, H.; Nagy, B.; Seppänen, J. K.; Salvador, A. F.; Mannila, H.; Saarinen-Pihkala, U. M.; Knuutila, S.

In: Leukemia, Vol. 16, No. 11, 01.11.2002, p. 2213-2221.

Research output: Contribution to journalArticle

Niini, T, Vettenranta, K, Hollmén, J, Larramendy, ML, Aalto, Y, Wikman, H, Nagy, B, Seppänen, JK, Salvador, AF, Mannila, H, Saarinen-Pihkala, UM & Knuutila, S 2002, 'Expression of myeloid-specific genes in childhood acute lymphoblastic leukemia - A cDNA array study', Leukemia, vol. 16, no. 11, pp. 2213-2221. https://doi.org/10.1038/sj.leu.2402685
Niini T, Vettenranta K, Hollmén J, Larramendy ML, Aalto Y, Wikman H et al. Expression of myeloid-specific genes in childhood acute lymphoblastic leukemia - A cDNA array study. Leukemia. 2002 Nov 1;16(11):2213-2221. https://doi.org/10.1038/sj.leu.2402685
Niini, T. ; Vettenranta, K. ; Hollmén, J. ; Larramendy, M. L. ; Aalto, Y. ; Wikman, H. ; Nagy, B. ; Seppänen, J. K. ; Salvador, A. F. ; Mannila, H. ; Saarinen-Pihkala, U. M. ; Knuutila, S. / Expression of myeloid-specific genes in childhood acute lymphoblastic leukemia - A cDNA array study. In: Leukemia. 2002 ; Vol. 16, No. 11. pp. 2213-2221.
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