Expression of invasion markers CD44v6/v3, NM23 and MMP2 in laryngeal and hypopharyngeal carcinoma

G. Répássy, Csaba Forster-Horváth, A. Juhász, R. Ádány, Anna Tamássy, J. Tímár

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Abstract

Twelve laryngeal squamous cell carcinoma cases (7 laryngeal and 5 hypopharyngeal cancer; 15 samples) were analysed by immunohistochemistry for the expression of invasion markers CD44v6/v3, NM23 and matrix metalloproteinase, MMP2. The laryngeal epithelium showed CD44v6+/v3+/NM23- /MMP2- phenotype. When tumors were grouped into TNM categories the phenotype of the T2 and T3 tumors was similar, characterised by decreased CD44v3+ and lack of MMP2 expressions. Meanwhile the NM23 expression was more frequent in T3 tumors. In T4 stage the frequency of NM23 and MMP2 positive cases increased (5/6 and 4/6, respectively) but there was no correlation with the appearence of lymph node metastasis. Comparison of the phenotype of laryngeal and hypopharyngeal tumors, irrespective of the TNM stages, revealed characteristic differences: T2 stage laryngeal tumors showed decreased CD44v3 and occasional NM23 and MMP2 positivity, while in T3 stage these tumors were characterised by 'increased frequency of NM23 positivity. The phenotype of the hypopharyngeal tumors was significantly difference with a high frequency of MMP2 positive cases (5/6) and NM23+/low CD44v3+ phenotype. The sharp differences in the phenotypes of laryngeal and hypopharyngeal carcinomas were connected to the differences in their invasive capacity unlike to the size of the tumors, since the T4 stage hypopharyngeal tumors had a significantly smaller size than laryngeal ones, even at lower stages.

Original languageEnglish
Pages (from-to)14-21
Number of pages8
JournalPathology and Oncology Research
Volume4
Issue number1
Publication statusPublished - 1998

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Carcinoma
Phenotype
Neoplasms
Laryngeal Mucosa
Hypopharyngeal Neoplasms
Matrix Metalloproteinases
Squamous Cell Carcinoma
Lymph Nodes
Immunohistochemistry
Neoplasm Metastasis

Keywords

  • CD44v3
  • Immunohistochemistry
  • Laryngeal carcinoma
  • MMP2
  • nm23

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pathology and Forensic Medicine

Cite this

Expression of invasion markers CD44v6/v3, NM23 and MMP2 in laryngeal and hypopharyngeal carcinoma. / Répássy, G.; Forster-Horváth, Csaba; Juhász, A.; Ádány, R.; Tamássy, Anna; Tímár, J.

In: Pathology and Oncology Research, Vol. 4, No. 1, 1998, p. 14-21.

Research output: Contribution to journalArticle

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