Expression of HLA-DR antigens by thyroid cells: the effect of Graves' IgG

Edith Bodolay, Gyula Szegedi, Peter Suranyi, Ferenc Juhasz, Valeria Stenszky, Csaba Balazs, Nadir R. Farid

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We have investigated factors which influence HLA-DR expression on thyroid cells. While bTSH (100 mU/ml) did not enhance HLA-DR expression, it increased when brought about by IFN-γ. Graves' IgG showed a dose-dependent (0.1-2 mg/ml) increase in DR expression and at a concentration of 2 mg/ml prolonged the time for which DR was expressed. The pathway of DR induction by Graves' IgG apparently differs from that by IFN-γ. The humoral response in Graves' disease, by inducing DR expression, may be instrumental in propagating thyroid specific autoimmunity.

Original languageEnglish
Pages (from-to)77-81
Number of pages5
JournalImmunology letters
Volume15
Issue number1
DOIs
Publication statusPublished - May 1987

Keywords

  • Graves' IgG
  • HLA-DR antigens
  • IFN-γ
  • Thyroid epithelial cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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