Expression of growth hormone-releasing hormone receptors in apocrine adnexal tumours and apocrine glands of the skin

Bence Kővári, Lajos Kocsis, Erika Varga, G. Cserni

Research output: Contribution to journalArticle

Abstract

Encouraged by our previous finding of growth hormone-releasing hormone receptor (GHRH-R) expression in metaplastic and neoplastic apocrine breast epithelium, we examined a small series of skin adnexal tumours with various degrees of apocrine (oxyphilic) differentiation, as well as normal axillary and anogenital apocrine sweat glands, for the expression of GHRH-R. Sections of formalin-fixed paraffin-embedded tissue blocks were immunostained for gross cystic disease fluid protein-15 (GCDFP-15) and androgen receptor (AR), to prove apocrine differentiation and correlate it with areas of GHRH-R expression. All but one of 19 tumours with apocrine epithelium and all five benign apocrine glands stained with both anti-GHRH-R antibodies used, each labelling a different domain of the receptor. Non-apocrine areas of the tumours and four eccrine tumours without oxyphilic features did not stain, but most sebaceous glands and some eccrine glands were labelled. Our data suggest that anti-GHRH-R antibodies highlight apocrine differentiation at extramammary sites also. Although GHRH-R seems to have a sensitivity comparable to classic apocrine markers such as AR and GCDFP-15, it seems to be inferior in specificity. The GHRH-R labelling of apocrine glands and neoplastic epithelium might also interfere with the emerging anti-GHRH targeted treatment of some malignancies acting on these receptors.

Original languageEnglish
Pages (from-to)48-52
Number of pages5
JournalPolish Journal of Pathology
Volume69
Issue number1
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

Apocrine Glands
Skin
Neoplasms
Epithelium
Androgen Receptors
Eccrine Glands
Sebaceous Glands
Sweat Glands
Antibodies
Paraffin
Formaldehyde
somatotropin releasing hormone receptor
Proteins
Breast
Coloring Agents

Keywords

  • Apocrine gland
  • Growth hormone-releasing hormone receptor
  • Immunohistochemistry
  • Skin adnexal tumours
  • Sweat gland

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Expression of growth hormone-releasing hormone receptors in apocrine adnexal tumours and apocrine glands of the skin. / Kővári, Bence; Kocsis, Lajos; Varga, Erika; Cserni, G.

In: Polish Journal of Pathology, Vol. 69, No. 1, 01.01.2018, p. 48-52.

Research output: Contribution to journalArticle

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