Expression of CD44v3 splice variant is associated with the visceral metastatic phenotype of human melanoma

B. Döme, B. Somlai, A. Ladányi, Károly Fazekas, Margot Zöller, J. Tímár

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

We analyzed the immunohistochemical expression of the metastasis-associated protein, CD44v3, in 46 primary human malignant melanomas (MMs). This is the first time that the v3 splice variant of CD44 was found to be expressed in human melanomas (15 of 46), ranging from 3% to 35% of the cell population in the positive tumors. The expression of CD44v3 was observed in tumors thicker than 1.0 mm, and one-third of these tumors proved to be positive irrespective of the thickness. Patients were followed for a minimum of 61 months. The onset of lymph node or organ metastases occurred not later than 58 months and 60 months, respectively. Of the 15 CD44v3 positive tumors, 14 were observed in the organ metastatic tumor group, comprising the majority of those cases (14 of 21), and this association proved to be statistically significant compared with the non-metastatic (P

Original languageEnglish
Pages (from-to)628-635
Number of pages8
JournalVirchows Archiv
Volume439
Issue number5
Publication statusPublished - 2001

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Melanoma
Phenotype
Neoplasms
Neoplasm Metastasis
Lymph Nodes
Population
Proteins

Keywords

  • CD44v3
  • Immunohistochemistry
  • Malignant melanoma
  • Metastasis
  • MMP2
  • RT-PCR

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Expression of CD44v3 splice variant is associated with the visceral metastatic phenotype of human melanoma. / Döme, B.; Somlai, B.; Ladányi, A.; Fazekas, Károly; Zöller, Margot; Tímár, J.

In: Virchows Archiv, Vol. 439, No. 5, 2001, p. 628-635.

Research output: Contribution to journalArticle

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AU - Zöller, Margot

AU - Tímár, J.

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