Biopsy specimens, taken from intracutaneous test reactions of 72 hours duration using interferon-gamma (rIFN-γ) or its diluent, and additional biopsies of untreated skin were studied in 4 healthy volunteers applying the monoclonal antibodies Leu anti-HLA-DR, Leu anti-CR2 (CD21) and OKMI (CR3, CD11b) by means of a multistep immunoperoxidase method. In contrast to untreated skin and to skin treated only with the diluent, subcorneal keratinocytes were found to express CD21 in all biopsies from rIFN-γ treated areas. This finding indicates, that CD21 also belongs to those molecules (HLA-DR-CD54) which can be upregulated by rIFN-γ on normal human keratinocytes in vivo.
|Translated title of the contribution||Expression of CD21 (receptor for C3d) of human keratinocytes in vivo after stimulation with interferon-gamma|
|Number of pages||3|
|Journal||H+G Zeitschrift fur Hautkrankheiten|
|Publication status||Published - Dec 1 1991|
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