CD21-(KOMPLEMENTREZEPTOR-)EXPRESSION HUMANER KERATINOZYTEN IN VIVO NACH STIMULATION MIT GAMMA-INTERFERON

Translated title of the contribution: Expression of CD21 (receptor for C3d) of human keratinocytes in vivo after stimulation with interferon-gamma

M. Simon, J. Hunyadi

Research output: Contribution to journalArticle

Abstract

Biopsy specimens, taken from intracutaneous test reactions of 72 hours duration using interferon-gamma (rIFN-γ) or its diluent, and additional biopsies of untreated skin were studied in 4 healthy volunteers applying the monoclonal antibodies Leu anti-HLA-DR, Leu anti-CR2 (CD21) and OKMI (CR3, CD11b) by means of a multistep immunoperoxidase method. In contrast to untreated skin and to skin treated only with the diluent, subcorneal keratinocytes were found to express CD21 in all biopsies from rIFN-γ treated areas. This finding indicates, that CD21 also belongs to those molecules (HLA-DR-CD54) which can be upregulated by rIFN-γ on normal human keratinocytes in vivo.

Translated title of the contributionExpression of CD21 (receptor for C3d) of human keratinocytes in vivo after stimulation with interferon-gamma
Original languageGerman
Pages (from-to)1051-1053
Number of pages3
JournalH+G Zeitschrift fur Hautkrankheiten
Volume66
Issue number12
Publication statusPublished - Dec 1 1991

ASJC Scopus subject areas

  • Dermatology

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