Expression of caveolin-1 in gastrointestinal and extraintestinal cancers

Márk Juhász, Jie Chen, Zsolt Tulassay, Peter Malfertheiner, Matthias P.A. Ebert

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

Caveolae are uniform vesicular invaginations of the cell membrane. Caveolin-1 is responsible for the formation of caveolae and plays a key role in membrane traffic and signal transduction. The contribution of caveolin-1 to carcinogenesis has been widely investigated; however, the expression pattern of caveolin-1 is controversial both in gastrointestinal and extraintestinal cancers. Most of the results based on cancer cell line experiments suggest that caveolin-1 might act as a tumor-suppressor gene. On the contrary, several studies on the expression of caveolin-1 in tumor tissues indicate a possible tumor-promoting effect of caveolin-1. In this article we summarize the divergent results of caveolin-1 expression in gastrointestinal and extraintestinal cancer regarding possible future therapeutic implications.

Original languageEnglish
Pages (from-to)493-497
Number of pages5
JournalJournal of cancer research and clinical oncology
Volume129
Issue number9
DOIs
Publication statusPublished - Sep 1 2003

Keywords

  • Caveolin-1
  • Extraintestinal cancer
  • Gastrointestinal cancer
  • Tumor-suppressor gene

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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