Expression of Ca 2+ -Binding Buffer Proteins in the Human and Mouse Retinal Neurons

Tamás Kovács-Öller, Gergely Szarka, Alma Ganczer, Ádám Tengölics, Boglárka Balogh, B. Völgyi

Research output: Contribution to journalReview article

Abstract

Ca2+-binding buffer proteins (CaBPs) are widely expressed by various neurons throughout the central nervous system (CNS), including the retina. While the expression of CaBPs by photoreceptors, retinal interneurons and the output ganglion cells in the mammalian retina has been extensively studied, a general description is still missing due to the differences between species, developmental expression patterns and study-to-study discrepancies. Furthermore, CaBPs are occasionally located in a compartment-specific manner and two or more CaBPs can be expressed by the same neuron, thereby sharing the labor of Ca2+ buffering in the intracellular milieu. This article reviews this topic by providing a framework on CaBP functional expression by neurons of the mammalian retina with an emphasis on human and mouse retinas and the three most abundant and extensively studied buffer proteins: parvalbumin, calretinin and calbindin.

Original languageEnglish
JournalInternational journal of molecular sciences
Volume20
Issue number9
DOIs
Publication statusPublished - May 7 2019

Fingerprint

Retinal Neurons
neurons
Neurons
mice
Buffers
retina
buffers
Carrier Proteins
proteins
Proteins
Retina
Calbindin 2
Calbindins
Parvalbumins
photoreceptors
Vertebrate Photoreceptor Cells
central nervous system
labor
Neurology
Interneurons

Keywords

  • Ca2+, retina
  • calbindin
  • calretinin
  • neuron
  • parvalbumin

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Expression of Ca 2+ -Binding Buffer Proteins in the Human and Mouse Retinal Neurons . / Kovács-Öller, Tamás; Szarka, Gergely; Ganczer, Alma; Tengölics, Ádám; Balogh, Boglárka; Völgyi, B.

In: International journal of molecular sciences, Vol. 20, No. 9, 07.05.2019.

Research output: Contribution to journalReview article

Kovács-Öller, Tamás ; Szarka, Gergely ; Ganczer, Alma ; Tengölics, Ádám ; Balogh, Boglárka ; Völgyi, B. / Expression of Ca 2+ -Binding Buffer Proteins in the Human and Mouse Retinal Neurons In: International journal of molecular sciences. 2019 ; Vol. 20, No. 9.
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