Expression of c-Met receptor and hepatocyte growth factor/scatter factor in synovial sarcoma and epithelioid sarcoma

Cornelius Kuhnen, Edina Tolnay, Hans Ulrich Steinau, Bruno Voss, Klaus Michael Müller

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Overexpression of c-Met receptor/hepatocyte growth factor (scatter factor) system (c-Met/HGF/SF) as a physiologically paracrine cellular signaling system is thought to be involved in the progression of malignant tumours. In 26 synovial sarcomas and epithelioid sarcomas, c-Met and HGF/SF expression was analysed immunohistochemically. There were 10 biphasic synovial sarcomas, 7 of which showed moderate to strong c-Met expression in epithelial areas compared with the fibrous component, with corresponding expression of HGF/SF. Six of 9 monophasic fibrous synovial sarcomas showed only very faint c-Met and corresponding HCF/SF expression. In 7 epithelioid sarcomas strong expression of c-Met and HGF/SF was observed within epithelioid tumour cells. Non-radioactive in situ hybridization demonstrated the synthesis of c-Met receptor in tumor cells by detecting c-met-mRNA. This analysis shows that in synovial sarcomas and epithelioid sarcomas, tumour entities with epithelial and mesenchymal structures, c-Met and HGF/SF overexpression can be detected, indicating a role of this signaling system in these subtypes of sarcoma, and especially in the more epithelioid tumour phenotype. An autocrine interaction between overexpressed c-Met receptor and HGF/SF may be hypothesized.

Original languageEnglish
Pages (from-to)337-342
Number of pages6
JournalVirchows Archiv
Volume432
Issue number4
DOIs
Publication statusPublished - 1998

Fingerprint

Proto-Oncogene Proteins c-met
Synovial Sarcoma
Hepatocyte Growth Factor
Sarcoma
Neoplasms
Paracrine Communication
Epithelioid Cells
In Situ Hybridization
Phenotype
Messenger RNA

Keywords

  • c-Met receptor
  • Epithelioid sarcoma
  • Hepatocyte growth factor/scatter factor
  • Synovial sarcoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Expression of c-Met receptor and hepatocyte growth factor/scatter factor in synovial sarcoma and epithelioid sarcoma. / Kuhnen, Cornelius; Tolnay, Edina; Steinau, Hans Ulrich; Voss, Bruno; Müller, Klaus Michael.

In: Virchows Archiv, Vol. 432, No. 4, 1998, p. 337-342.

Research output: Contribution to journalArticle

Kuhnen, Cornelius ; Tolnay, Edina ; Steinau, Hans Ulrich ; Voss, Bruno ; Müller, Klaus Michael. / Expression of c-Met receptor and hepatocyte growth factor/scatter factor in synovial sarcoma and epithelioid sarcoma. In: Virchows Archiv. 1998 ; Vol. 432, No. 4. pp. 337-342.
@article{0af8c24755b04d6b89b1a7266e96de42,
title = "Expression of c-Met receptor and hepatocyte growth factor/scatter factor in synovial sarcoma and epithelioid sarcoma",
abstract = "Overexpression of c-Met receptor/hepatocyte growth factor (scatter factor) system (c-Met/HGF/SF) as a physiologically paracrine cellular signaling system is thought to be involved in the progression of malignant tumours. In 26 synovial sarcomas and epithelioid sarcomas, c-Met and HGF/SF expression was analysed immunohistochemically. There were 10 biphasic synovial sarcomas, 7 of which showed moderate to strong c-Met expression in epithelial areas compared with the fibrous component, with corresponding expression of HGF/SF. Six of 9 monophasic fibrous synovial sarcomas showed only very faint c-Met and corresponding HCF/SF expression. In 7 epithelioid sarcomas strong expression of c-Met and HGF/SF was observed within epithelioid tumour cells. Non-radioactive in situ hybridization demonstrated the synthesis of c-Met receptor in tumor cells by detecting c-met-mRNA. This analysis shows that in synovial sarcomas and epithelioid sarcomas, tumour entities with epithelial and mesenchymal structures, c-Met and HGF/SF overexpression can be detected, indicating a role of this signaling system in these subtypes of sarcoma, and especially in the more epithelioid tumour phenotype. An autocrine interaction between overexpressed c-Met receptor and HGF/SF may be hypothesized.",
keywords = "c-Met receptor, Epithelioid sarcoma, Hepatocyte growth factor/scatter factor, Synovial sarcoma",
author = "Cornelius Kuhnen and Edina Tolnay and Steinau, {Hans Ulrich} and Bruno Voss and M{\"u}ller, {Klaus Michael}",
year = "1998",
doi = "10.1007/s004280050175",
language = "English",
volume = "432",
pages = "337--342",
journal = "Virchows Archiv - A Pathological Anatomy and Histopathology",
issn = "0945-6317",
publisher = "Springer Verlag",
number = "4",

}

TY - JOUR

T1 - Expression of c-Met receptor and hepatocyte growth factor/scatter factor in synovial sarcoma and epithelioid sarcoma

AU - Kuhnen, Cornelius

AU - Tolnay, Edina

AU - Steinau, Hans Ulrich

AU - Voss, Bruno

AU - Müller, Klaus Michael

PY - 1998

Y1 - 1998

N2 - Overexpression of c-Met receptor/hepatocyte growth factor (scatter factor) system (c-Met/HGF/SF) as a physiologically paracrine cellular signaling system is thought to be involved in the progression of malignant tumours. In 26 synovial sarcomas and epithelioid sarcomas, c-Met and HGF/SF expression was analysed immunohistochemically. There were 10 biphasic synovial sarcomas, 7 of which showed moderate to strong c-Met expression in epithelial areas compared with the fibrous component, with corresponding expression of HGF/SF. Six of 9 monophasic fibrous synovial sarcomas showed only very faint c-Met and corresponding HCF/SF expression. In 7 epithelioid sarcomas strong expression of c-Met and HGF/SF was observed within epithelioid tumour cells. Non-radioactive in situ hybridization demonstrated the synthesis of c-Met receptor in tumor cells by detecting c-met-mRNA. This analysis shows that in synovial sarcomas and epithelioid sarcomas, tumour entities with epithelial and mesenchymal structures, c-Met and HGF/SF overexpression can be detected, indicating a role of this signaling system in these subtypes of sarcoma, and especially in the more epithelioid tumour phenotype. An autocrine interaction between overexpressed c-Met receptor and HGF/SF may be hypothesized.

AB - Overexpression of c-Met receptor/hepatocyte growth factor (scatter factor) system (c-Met/HGF/SF) as a physiologically paracrine cellular signaling system is thought to be involved in the progression of malignant tumours. In 26 synovial sarcomas and epithelioid sarcomas, c-Met and HGF/SF expression was analysed immunohistochemically. There were 10 biphasic synovial sarcomas, 7 of which showed moderate to strong c-Met expression in epithelial areas compared with the fibrous component, with corresponding expression of HGF/SF. Six of 9 monophasic fibrous synovial sarcomas showed only very faint c-Met and corresponding HCF/SF expression. In 7 epithelioid sarcomas strong expression of c-Met and HGF/SF was observed within epithelioid tumour cells. Non-radioactive in situ hybridization demonstrated the synthesis of c-Met receptor in tumor cells by detecting c-met-mRNA. This analysis shows that in synovial sarcomas and epithelioid sarcomas, tumour entities with epithelial and mesenchymal structures, c-Met and HGF/SF overexpression can be detected, indicating a role of this signaling system in these subtypes of sarcoma, and especially in the more epithelioid tumour phenotype. An autocrine interaction between overexpressed c-Met receptor and HGF/SF may be hypothesized.

KW - c-Met receptor

KW - Epithelioid sarcoma

KW - Hepatocyte growth factor/scatter factor

KW - Synovial sarcoma

UR - http://www.scopus.com/inward/record.url?scp=0031944886&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031944886&partnerID=8YFLogxK

U2 - 10.1007/s004280050175

DO - 10.1007/s004280050175

M3 - Article

VL - 432

SP - 337

EP - 342

JO - Virchows Archiv - A Pathological Anatomy and Histopathology

JF - Virchows Archiv - A Pathological Anatomy and Histopathology

SN - 0945-6317

IS - 4

ER -