Expression of a 268 proteasome ATPase subunit, MS73, in muscles that undergo developmentally programmed cell death, and its control by ecdysteroid hormones in the insect Manduca sexta

P. Löw, K. Bussell, S. P. Dawson, M. A. Billett, R. J. Mayer, S. E. Reynolds

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

MS73, an ATPase regulatory subunit of the 26S proteasome in the moth Manduca sexta, is shown to be expressed at a high level only in muscles that are undergoing developmentally programmed cell death, or which are destined to do so. The amount of MS73 is increased by more than two-fold just before death in each of three different muscles that die at different times, under different developmental controls. An ecdysteroid (moulting hormone) agonist, RH-5849, that prevents the occurrence of programmed cell death in two of these muscles also prevents the normally occurring rise in level of MS73 in these muscles. This evidence is consistent with a role for MS73 in programmed cell death.

Original languageEnglish
Pages (from-to)345-349
Number of pages5
JournalFEBS letters
Volume400
Issue number3
DOIs
Publication statusPublished - Jan 6 1997

Keywords

  • ATPase
  • Ecdysteroid agonist
  • Manduca sexta
  • Programmed cell death
  • Proteasome
  • RH-5849

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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