Expression and role of CR1 and CR2 on B and T lymphocytes under physiological and autoimmune conditions

Anna Erdei, Andrea Isaák, Katalin Török, Noémi Sándor, Mariann Kremlitzka, József Prechl, Zsuzsa Bajtay

Research output: Contribution to journalReview article

49 Citations (Scopus)

Abstract

The involvement of complement in the development and regulation of antibody responses under both healthy and pathological conditions is known for long. Unravelling the molecular mechanisms underlying the events however is still in progress. This review focuses on the role of complement receptors CR1 (CD35) and CR2 (CD21) expressed on T and B cells. Alteration in the expression and function of these receptors may contribute to the initiation and maintenance of immune complex mediated autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. Recent data regarding complement receptor expression on T lymphocytes and on memory B cells are also discussed.

Original languageEnglish
Pages (from-to)2767-2773
Number of pages7
JournalMolecular Immunology
Volume46
Issue number14
DOIs
Publication statusPublished - Sep 1 2009

Keywords

  • Autoimmunity
  • B and T lymphocytes
  • CR1 (CD35)
  • CR2 (CD21)
  • Complement receptors
  • Immune response

ASJC Scopus subject areas

  • Immunology
  • Molecular Biology

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