Expression and localization of vascular endothelial growth factor and its receptor flt in pulmonary sarcoidosis

E. Tolnay, Cornelius Kuhnen, Bruno Voss, Thorsten Wiethege, Klaus Michael Müller

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Vascular endothelial growth factor (VEGF) is a multifunctional cytokine, which has recently been reported to enhance the activation and migration of monocytes through the flt receptor in vitro, which are key events in granuloma formation of granulomatous disorders and in sarcoidosis. Since activated macrophages and monocytes are known to be involved in sarcoid granuloma formation in sarcoidosis, we investigated the expression of VEGF and its receptor flt in 33 paraffin-embedded lung tissue biopsies of patients with pulmonary sarcoidosis. VEGF-mRNA was localized by nonradioactive in situ hybridization, VEGF and flt expression were visualized immunohistochemically. We found an increased transcription and protein production of VEGF and an overexpression of flt in activated alveolar macrophages, in epitheloid cells, and in multinuclear giant cells of pulmonary sarcoid granulomas.

Original languageEnglish
Pages (from-to)61-65
Number of pages5
JournalVirchows Archiv
Volume432
Issue number1
DOIs
Publication statusPublished - 1998

Fingerprint

Pulmonary Sarcoidosis
Vascular Endothelial Growth Factor Receptor
Vascular Endothelial Growth Factor A
Granuloma
Sarcoidosis
Monocytes
Lung
Alveolar Macrophages
Giant Cells
Paraffin
In Situ Hybridization
Macrophages
Cytokines
Biopsy
Messenger RNA
Proteins

Keywords

  • Activated macrophage
  • flt
  • Pulmonary sarcoidosis
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Expression and localization of vascular endothelial growth factor and its receptor flt in pulmonary sarcoidosis. / Tolnay, E.; Kuhnen, Cornelius; Voss, Bruno; Wiethege, Thorsten; Müller, Klaus Michael.

In: Virchows Archiv, Vol. 432, No. 1, 1998, p. 61-65.

Research output: Contribution to journalArticle

Tolnay, E. ; Kuhnen, Cornelius ; Voss, Bruno ; Wiethege, Thorsten ; Müller, Klaus Michael. / Expression and localization of vascular endothelial growth factor and its receptor flt in pulmonary sarcoidosis. In: Virchows Archiv. 1998 ; Vol. 432, No. 1. pp. 61-65.
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