Exposure of consumers to morphine from poppy seeds in Hungary

A. Zentai, J. Sali, M. Szeitzné-Szabó, I. J. Szabó, A. Ámbrus

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Poppy seed-containing foods are popular dishes in Hungary and some other Central European countries. The alkaloids of poppy are used in the production of medicines. Poppy seeds used as food may also contain considerable amounts of alkaloids, which raises the question of food safety. Morphine, codeine, thebaine and noscapine concentrations of poppy seed samples from the period 2001-2010 and consumption data from two Hungarian surveys, carried out in 2003 and 2009, were evaluated. Exposure calculations were made for morphine intake by both point estimate and probabilistic methods, and the uncertainty of the calculated values was estimated. The point estimate for the acute consumer exposure, calculated using the 97.5th percentiles of morphine concentration and of poppy seed consumption and taking into account the reduction of morphine content by processing, was 78.64 μg (kg bw) -1 day -1 for adults, and 116.90 μg (kg bw) -1day -1 for children. Based on probabilistic estimations, the 97.5th and 99th percentile exposures ranged between 18.3-25.4 and 25.6-47.4 μg (kg bw) -1day -1 for adults, and between 32.9 and 66.4 μg (kg bw) -1 day -1 for children, respectively. As a no observed effect level (NOEL) had not been established, the significance of exposure could not be assessed.

Original languageEnglish
Pages (from-to)403-414
Number of pages12
JournalFood Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment
Volume29
Issue number3
Publication statusPublished - Mar 2012

Fingerprint

Papaver
Hungary
morphine
Morphine
Seed
Seeds
seeds
Alkaloids
alkaloids
Thebaine
Noscapine
thebaine
codeine
Food safety
no observed adverse effect level
Codeine
No-Observed-Adverse-Effect Level
Food
Central European region
Food Safety

Keywords

  • Exposure - probability modeling
  • Exposure assessment
  • Natural toxicants - alkaloids

ASJC Scopus subject areas

  • Food Science
  • Health, Toxicology and Mutagenesis
  • Public Health, Environmental and Occupational Health
  • Toxicology
  • Chemistry(all)

Cite this

Exposure of consumers to morphine from poppy seeds in Hungary. / Zentai, A.; Sali, J.; Szeitzné-Szabó, M.; Szabó, I. J.; Ámbrus, A.

In: Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment, Vol. 29, No. 3, 03.2012, p. 403-414.

Research output: Contribution to journalArticle

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