Exploring the intramolecular catalysis of the proton exchange process to modulate the relaxivity of Gd(iii)-complexes of HP-DO3A-like ligands

Irene Maria Carnovale, Marco Lucio Lolli, Sonia Colombo Serra, Alberto Fringuello Mingo, Roberta Napolitano, Valeria Boi, Nicol Guidolin, Luciano Lattuada, Fabio Tedoldi, Zsolt Baranyai, Silvio Aime

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The Gd(iii)-complexes of three novel HP-DO3A-like ligands have been investigated to assess the relationship between relaxometry and intramolecular catalysis of the proton exchange. The structures of these ligands differ from the parent HP-DO3A because the methyl group of the hydroxy-propyl arm has been replaced by-Ph-OH,-Ph-NH2 and-Ph-COOH, respectively. The phenol, amine and carboxylate functionalities display an intramolecular H-bonding with the coordinated hydroxyl moiety that affects either the pK values of the involved functionalities and the rate of the proton exchange process.

Original languageEnglish
Pages (from-to)10056-10059
Number of pages4
JournalChemical Communications
Volume54
Issue number72
DOIs
Publication statusPublished - Jan 1 2018

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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  • Cite this

    Carnovale, I. M., Lolli, M. L., Serra, S. C., Mingo, A. F., Napolitano, R., Boi, V., Guidolin, N., Lattuada, L., Tedoldi, F., Baranyai, Z., & Aime, S. (2018). Exploring the intramolecular catalysis of the proton exchange process to modulate the relaxivity of Gd(iii)-complexes of HP-DO3A-like ligands. Chemical Communications, 54(72), 10056-10059. https://doi.org/10.1039/C8CC05284K