Exploring mechanisms leading to robust biochemical systems

Zs Nagy, B. Bertók, F. Friedler, D. Y. Lee, L. T. Fan, S. Shafie

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Cell robustness and complexity have been recognized as unique features of biological systems. This is attributable to the existence of multiple (or redundant) metabolic pathways and the concomitant multiple flux distributions, with each pathway leading to a single phenotype. Moreover, the multiple pathways may result in a variety of products or byproducts under different environmental conditions, e.g., substrate concentration, PH, and temperature. Appropriately controlling environmental or genetic conditions renders it possible to maximize the rate of substrate conversion and the production of a desired product or products by circumventing the occurrence of the secondary reactions yielding undesirable intermediates and byproducts. As such, we would enable us to devise or design biochemical manufacturing processes with enhanced energy efficiency and robustness; the resultant processes would be capable of increasing the rates of production, thereby lowering their costs. Proposed herein is an effective approach for exploring metabolic pathways, which algorithmically synthesizes all the candidate pathways by a rigorous graph-theoretic method based on P-graphs (process graphs).

Original languageEnglish
Title of host publicationCHISA 2006 - 17th International Congress of Chemical and Process Engineering
Publication statusPublished - 2006
EventCHISA 2006 - 17th International Congress of Chemical and Process Engineering - Prague, Czech Republic
Duration: Aug 27 2006Aug 31 2006

Other

OtherCHISA 2006 - 17th International Congress of Chemical and Process Engineering
CountryCzech Republic
CityPrague
Period8/27/068/31/06

Fingerprint

Byproducts
Biological systems
Substrates
Energy efficiency
Fluxes
Costs
Temperature
Metabolic Networks and Pathways

ASJC Scopus subject areas

  • Chemical Engineering(all)

Cite this

Nagy, Z., Bertók, B., Friedler, F., Lee, D. Y., Fan, L. T., & Shafie, S. (2006). Exploring mechanisms leading to robust biochemical systems. In CHISA 2006 - 17th International Congress of Chemical and Process Engineering

Exploring mechanisms leading to robust biochemical systems. / Nagy, Zs; Bertók, B.; Friedler, F.; Lee, D. Y.; Fan, L. T.; Shafie, S.

CHISA 2006 - 17th International Congress of Chemical and Process Engineering. 2006.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Nagy, Z, Bertók, B, Friedler, F, Lee, DY, Fan, LT & Shafie, S 2006, Exploring mechanisms leading to robust biochemical systems. in CHISA 2006 - 17th International Congress of Chemical and Process Engineering. CHISA 2006 - 17th International Congress of Chemical and Process Engineering, Prague, Czech Republic, 8/27/06.
Nagy Z, Bertók B, Friedler F, Lee DY, Fan LT, Shafie S. Exploring mechanisms leading to robust biochemical systems. In CHISA 2006 - 17th International Congress of Chemical and Process Engineering. 2006
Nagy, Zs ; Bertók, B. ; Friedler, F. ; Lee, D. Y. ; Fan, L. T. ; Shafie, S. / Exploring mechanisms leading to robust biochemical systems. CHISA 2006 - 17th International Congress of Chemical and Process Engineering. 2006.
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