Exploring in-hospital death from myocardial infarction in Eastern Europe: From the international registry of acute coronary syndromes in transitional countries (ISACS-TC); on the behalf of the working group on coronary pathophysiology & microcirculation of the European Society of Cardiology

Raffaele Bugiardini, Olivia Manfrini, Marta Majstorović Stakić, Edina Cenko, Sergei Boytsov, Béla Merkely, David Becker, Mirza Dilić, Zorana Vasiljević, Akos Koller, Lina Badimon

Research output: Contribution to journalArticle

28 Citations (Scopus)


Introduction: The aim of the current study was to investigate the outcomes of coronary reperfusion therapies and ST-segment elevation myocardial infarction (STEMI) in patients of Eastern countries with economies in transition. Methods and Results: We received STEMI registry data from 4 countries: Bosnia and Herzegovina, Hungary, Russian Federation, and Serbia. The overall population consisted of 23,486 consecutive patients admitted to hospitals from January 1st to December 31st 2009. Registry data and statistics from the Organization for Economic Cooperation and Development (OECD) countries for the same period were used for comparison (2009-2010). In-hospital mortality was between 4% and 5% in the Western countries. In comparison mortality data were significantly larger in Serbia (10.8%) and Bosnia and Herzegovina (11.2%), intermediate in Russian Federation (7.2%) and similar in Hungary (5.0%). The rates of primary percutaneous coronary intervention (primary PCI) were very low in Bosnia and Herzegovina (18.3%), low in Russian Federation (20.6%) and Serbia (22%), and high in Hungary (70%). Major risk factors for death appear to be lack of reperfusion therapy, longer time delay from symptoms onset to hospital presentation as well as the higher percentage of patients with clinical presentation in Killip class III/IV. Conclusion: In-hospital STEMI case-fatality rates ranges widely in the former Eastern Bloc countries. Beyond the quality of care provided in hospitals, differences in time delay from symptoms onset to hospital admission may strongly influence STEMI patients’ outcome.

Original languageEnglish
Pages (from-to)903-909
Number of pages7
JournalCurrent Vascular Pharmacology
Issue number6
Publication statusPublished - Jan 1 2014



  • Acute myocardial infarction
  • Bosnia and Herzegovina
  • Hungary
  • Mortality rate
  • Reperfusion therapy
  • Russian Federation
  • Serbia

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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