Exploratory activity and conditioned avoidance acquisition after early postnatal 6-Hydroxydopamine administration

C. Nyakas, A. M.L. van Delft, J. Kaplanski, P. G. Smelik

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8 Citations (Scopus)


Newborn rats were treated with 3 injections of 6-hydroxydopamine (6-OHDA) either subcutaneously (s. c.) or intracerebrally (i. cer.).General motor activity, exploratory activities (crossing and rearing) and acquisition of conditioned avoidance response (CAR) in shuttle-box were tested in the course of the 9th postnatal week. 50 μg/g s. c. 6-OHDA injected daily during the first 3 postnatal days led to a moderate decrease in rearing but was ineffective on other behavioural parameters. A dose of 100 μg i. cer. (20, 30, 50 μg on days 2, 4, 6 resp.) resulted in a considerable reduction in both rearing and acquisition of CAR, while 200 μg i. cer. 6-OHDA (40, 60, 100 μg on days 2, 4, 6) induced a marked impairment in rearing and acquisition of CAR, and a less pronounced decrease in crossing activity. No significant change was found in general motor activity. Increasing doses of 6-OHDA led to an 80-90% depletion in brain catecholamines and induced a content-related behavioural suppression in rearing and conditioned avoidance responding in particular. It is concluded that intracerebral administration of 6-OHDA into neonatal rats almost completely prevents the development of central catecholaminergic neuronal systems, and concomitantly the capability of acquiring conditioned avoidance behaviour, while reducing exploratory behaviour.

Original languageEnglish
Pages (from-to)253-266
Number of pages14
JournalJournal of neural transmission
Issue number4
Publication statusPublished - Dec 1 1973


  • 6-hydroxydopamine
  • Exploratory activity
  • avoidance behaviour
  • catecholamines
  • neonatal treatment
  • rat

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

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