Exploiting the Proton Exchange as an Additional Route to Enhance the Relaxivity of Paramagnetic MRI Contrast Agents

Silvio Aime, Simona Baroni, Daniela Delli Castelli, E. Brücher, I. Fábián, Sonia Colombo Serra, Alberto Fringuello Mingo, Roberta Napolitano, Luciano Lattuada, Fabio Tedoldi, Z. Baranyai

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The relaxivity of Gd(HP-DO3A) was studied as a function of pH and buffer composition in order to identify the main factors of the observed relaxation enhancement due to the exchange of the coordinated hydroxyl proton. It was established that the paramagnetic relaxation time, T1M, of the coordinated hydroxyl proton is about 50% shorter than that of the protons in the coordinated water molecule. The control of the pK of the coordinated alcoholic -OH moiety in the ligand is fundamental to utilize the proton exchange enhanced relaxivity under physio/pathologic conditions. A new derivative of Gd(HP-DO3A) was synthesized by replacing the -CH3 group with a -CF3 moiety. In this complex, the -OH group becomes more acidic. Consequently, the maximum contribution of the proton exchange to the relaxivity is shifted to a lower pH region with the fluorinated ligand.

Original languageEnglish
Pages (from-to)5567-5574
Number of pages8
JournalInorganic Chemistry
Volume57
Issue number9
DOIs
Publication statusPublished - May 7 2018

Fingerprint

Magnetic resonance imaging
Contrast Media
Protons
routes
protons
Hydroxyl Radical
Ligands
ligands
Relaxation time
Buffers
buffers
relaxation time
Derivatives
Molecules
Water
augmentation
Chemical analysis
water
molecules
gadoteridol

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry

Cite this

Exploiting the Proton Exchange as an Additional Route to Enhance the Relaxivity of Paramagnetic MRI Contrast Agents. / Aime, Silvio; Baroni, Simona; Delli Castelli, Daniela; Brücher, E.; Fábián, I.; Serra, Sonia Colombo; Fringuello Mingo, Alberto; Napolitano, Roberta; Lattuada, Luciano; Tedoldi, Fabio; Baranyai, Z.

In: Inorganic Chemistry, Vol. 57, No. 9, 07.05.2018, p. 5567-5574.

Research output: Contribution to journalArticle

Aime, S, Baroni, S, Delli Castelli, D, Brücher, E, Fábián, I, Serra, SC, Fringuello Mingo, A, Napolitano, R, Lattuada, L, Tedoldi, F & Baranyai, Z 2018, 'Exploiting the Proton Exchange as an Additional Route to Enhance the Relaxivity of Paramagnetic MRI Contrast Agents', Inorganic Chemistry, vol. 57, no. 9, pp. 5567-5574. https://doi.org/10.1021/acs.inorgchem.8b00521
Aime, Silvio ; Baroni, Simona ; Delli Castelli, Daniela ; Brücher, E. ; Fábián, I. ; Serra, Sonia Colombo ; Fringuello Mingo, Alberto ; Napolitano, Roberta ; Lattuada, Luciano ; Tedoldi, Fabio ; Baranyai, Z. / Exploiting the Proton Exchange as an Additional Route to Enhance the Relaxivity of Paramagnetic MRI Contrast Agents. In: Inorganic Chemistry. 2018 ; Vol. 57, No. 9. pp. 5567-5574.
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