Exploitation of intestinal colonization-inhibition between Salmonella organisms for live vaccines in poultry - potential and limitations

U. Methner, A. Haase, A. Berndt, G. Martin, B. Nagy, P. A. Barrow

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Immunization represents one of the most important methods to increase the resistance of chickens against Salmonella infection. In addition to the development of an adaptive immune response, oral administration of live Salmonella strains to day-old chicks provides protection against infection within hours by intestinal colonization-inhibition. For the exploitation of this phenomenon, practical information on colonization-inhibition between Salmonella organisms is needed. Colonization-inhibition capacity between Salmonella strains from serogroups B, C1, C2, D and G was assessed in chickens. The most profound level of intestinal colonization-inhibition occurred between isogenic strains. Inhibition between strains of the same serovar was greater than that between strains of different serovars. The degree of inhibition between different serovars was not sufficiently high to identify a single strain which might inhibit a wide range of other Salmonella organisms. However, as Salmonella Enteritidis is the dominant serovar in poultry in many countries and because of the profound colonization-inhibition within this serovar there is a considerable potential to exploit this phenomenon in the development of novel live S. Enteritidis vaccines. Treatment of young chicks with mixtures of different Salmonella serovars resulted not only in a very strong growth inhibition of the isogenic strains but also in a substantial inhibition of heterologous serovars. The potential of mixtures of heterologous Salmonella strains as a 'Salmonella Inhibition Culture' and as a 'live Salmonella vaccine' should be further explored.

Original languageEnglish
Pages (from-to)540-548
Number of pages9
JournalZoonoses and Public Health
Volume58
Issue number8
DOIs
Publication statusPublished - Dec 1 2011

Keywords

  • Chicken
  • Intestinal colonization-inhibition
  • Salmonella

ASJC Scopus subject areas

  • Epidemiology
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Exploitation of intestinal colonization-inhibition between Salmonella organisms for live vaccines in poultry - potential and limitations'. Together they form a unique fingerprint.

  • Cite this