Experiments on prevention of the endotoxin-abortifacient effect by radiodetoxified endotoxin pretreatment in rats

Terèz Csordàs, Lôrând Bertôk, Zsolt Csapô

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Endotoxemia has been induced in pregnant rats by intravenous injection of 1 mg Escherichia coli endotoxin which resulted in intrauterine death and abortion of fetuses in 24 h. The abortifacient effect of endotoxin was prevented in 90% by 200 Mg radio- detoxified endotoxin, injected intravenously 24 h earlier. The authors suppose that the radiodetoxified endotoxin can be a good tool also in the prevention of human septic (endotoxin) shock in pregnancy.

Original languageEnglish
Pages (from-to)57-64
Number of pages8
JournalGynecologic and Obstetric Investigation
Volume9
Issue number1
DOIs
Publication statusPublished - Jan 1 1978

Keywords

  • Endotoxin-Abortifacient effect
  • Prevention
  • Radiodetoxified endotoxin

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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