Endotoxemia has been induced in pregnant rats by intravenous injection of 1 mg Escherichia coli endotoxin which resulted in intrauterine death and abortion of fetuses in 24 h. The abortifacient effect of endotoxin was prevented in 90% by 200 Mg radio- detoxified endotoxin, injected intravenously 24 h earlier. The authors suppose that the radiodetoxified endotoxin can be a good tool also in the prevention of human septic (endotoxin) shock in pregnancy.
- Endotoxin-Abortifacient effect
- Radiodetoxified endotoxin
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynaecology