Vascular prostheses of different porosity were applied in dogs. On their surfaces a triple layer regenerate resembling the arterial wall developed like an oriented structure, mainly from the mesenchymal cells of the environment. Morphological differentiation occurred in 3 directions: a collagenous connective tissue reaction appearing in the form of an oriented structure; specific vascular elements such as endothelium, smooth muscle and elastic fibres; and degenerative phenomena. Specific vascular elements appeared in the zones of the regenerate well supplied with blood, whereas the degenerative phenomena were observed in the poorly supplied areas. The 2 opposite phenomena lend themselves for an evaluation of the quality of the regenerate. The theoretical and practical causes of the limitations of the present vascular prostheses are discussed, suggesting the necessity of searching for more complete vascular substitutes. On the basis of the findings the authors attempt to define the requirements of an ideal vascular graft.
|Number of pages||21|
|Journal||Acta morphologica Academiae Scientiarum Hungaricae|
|Publication status||Published - Dec 1 1973|
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