Experimental validation of the influence of white matter anisotropy on the intracranial EEG forward solution

Nitin B. Bangera, Donald L. Schomer, Nima Dehghani, I. Ulbert, Sydney Cash, Steve Papavasiliou, Solomon R. Eisenberg, Anders M. Dale, Eric Halgren

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Forward solutions with different levels of complexity are employed for localization of current generators, which are responsible for the electric and magnetic fields measured from the human brain. The influence of brain anisotropy on the forward solution is poorly understood. The goal of this study is to validate an anisotropic model for the intracranial electric forward solution by comparing with the directly measured 'gold standard'. Dipolar sources are created at known locations in the brain and intracranial electroencephalogram (EEG) is recorded simultaneously. Isotropic models with increasing level of complexity are generated along with anisotropic models based on Diffusion tensor imaging (DTI). A Finite Element Method based forward solution is calculated and validated using the measured data. Major findings are (1) An anisotropic model with a linear scaling between the eigenvalues of the electrical conductivity tensor and water self-diffusion tensor in brain tissue is validated. The greatest improvement was obtained when the stimulation site is close to a region of high anisotropy. The model with a global anisotropic ratio of 10:1 between the eigenvalues (parallel: tangential to the fiber direction) has the worst performance of all the anisotropic models. (2) Inclusion of cerebrospinal fluid as well as brain anisotropy in the forward model is necessary for an accurate description of the electric field inside the skull. The results indicate that an anisotropic model based on the DTI can be constructed non-invasively and shows an improved performance when compared to the isotropic models for the calculation of the intracranial EEG forward solution.

Original languageEnglish
Pages (from-to)371-387
Number of pages17
JournalJournal of Computational Neuroscience
Volume29
Issue number3
DOIs
Publication statusPublished - Dec 2010

Fingerprint

Anisotropy
Electroencephalography
Brain
Diffusion Tensor Imaging
Electric Conductivity
Magnetic Fields
Skull
Cerebrospinal Fluid
White Matter
Water

Keywords

  • FEM
  • Finite element model
  • Forward solution
  • Intracranial EEG
  • Source localization
  • Validation
  • White matter anisotropy

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cognitive Neuroscience
  • Sensory Systems

Cite this

Experimental validation of the influence of white matter anisotropy on the intracranial EEG forward solution. / Bangera, Nitin B.; Schomer, Donald L.; Dehghani, Nima; Ulbert, I.; Cash, Sydney; Papavasiliou, Steve; Eisenberg, Solomon R.; Dale, Anders M.; Halgren, Eric.

In: Journal of Computational Neuroscience, Vol. 29, No. 3, 12.2010, p. 371-387.

Research output: Contribution to journalArticle

Bangera, NB, Schomer, DL, Dehghani, N, Ulbert, I, Cash, S, Papavasiliou, S, Eisenberg, SR, Dale, AM & Halgren, E 2010, 'Experimental validation of the influence of white matter anisotropy on the intracranial EEG forward solution', Journal of Computational Neuroscience, vol. 29, no. 3, pp. 371-387. https://doi.org/10.1007/s10827-009-0205-z
Bangera, Nitin B. ; Schomer, Donald L. ; Dehghani, Nima ; Ulbert, I. ; Cash, Sydney ; Papavasiliou, Steve ; Eisenberg, Solomon R. ; Dale, Anders M. ; Halgren, Eric. / Experimental validation of the influence of white matter anisotropy on the intracranial EEG forward solution. In: Journal of Computational Neuroscience. 2010 ; Vol. 29, No. 3. pp. 371-387.
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