Experimental study of the 165Ho(p,n) nuclear reaction for production of the therapeutic radioisotope 165Er

F. Tárkányi, A. Hermanne, S. Takács, F. Ditrói, B. Király, S. F. Kovalev, A. V. Ignatyuk

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11 Citations (Scopus)

Abstract

The 10.3 h half life radionuclide 165Er, decaying by electron capture to stable 165Ho, is an excellent candidate for Auger-electron therapy. In the frame of a systematic study of charged particle production routes of 165Er, the excitation function of the 165Ho(p,n)165Er reaction was measured up to 35 MeV by using a stacked foil irradiation technique and X-ray spectroscopy. The measured excitation function shows a significant energy shift when compared to the only experimental dataset measured earlier and an acceptable agreement with the results of different nuclear reaction model codes. The thick target yields calculated from the excitation function at typical energies available at small cyclotrons (Ep = 11 MeV and Ep = 15 MeV) are 41 MBq/μAh = 11 GBq/C and 75 MBq/μAh = 21 GBq/C, respectively.

Original languageEnglish
Pages (from-to)3346-3352
Number of pages7
JournalNuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms
Volume266
Issue number15
DOIs
Publication statusPublished - Aug 2008

Fingerprint

Nuclear reactions
Radioisotopes
nuclear reactions
excitation
Electrons
particle production
Cyclotrons
Charged particles
X ray spectroscopy
electron capture
half life
radioactive isotopes
Metal foil
cyclotrons
foils
therapy
charged particles
routes
Irradiation
irradiation

Keywords

  • Cross section
  • Excitation function
  • Holmium target
  • Proton irradiation
  • Therapeutic radioisotope

ASJC Scopus subject areas

  • Surfaces, Coatings and Films
  • Instrumentation
  • Surfaces and Interfaces

Cite this

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title = "Experimental study of the 165Ho(p,n) nuclear reaction for production of the therapeutic radioisotope 165Er",
abstract = "The 10.3 h half life radionuclide 165Er, decaying by electron capture to stable 165Ho, is an excellent candidate for Auger-electron therapy. In the frame of a systematic study of charged particle production routes of 165Er, the excitation function of the 165Ho(p,n)165Er reaction was measured up to 35 MeV by using a stacked foil irradiation technique and X-ray spectroscopy. The measured excitation function shows a significant energy shift when compared to the only experimental dataset measured earlier and an acceptable agreement with the results of different nuclear reaction model codes. The thick target yields calculated from the excitation function at typical energies available at small cyclotrons (Ep = 11 MeV and Ep = 15 MeV) are 41 MBq/μAh = 11 GBq/C and 75 MBq/μAh = 21 GBq/C, respectively.",
keywords = "Cross section, Excitation function, Holmium target, Proton irradiation, Therapeutic radioisotope",
author = "F. T{\'a}rk{\'a}nyi and A. Hermanne and S. Tak{\'a}cs and F. Ditr{\'o}i and B. Kir{\'a}ly and Kovalev, {S. F.} and Ignatyuk, {A. V.}",
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TY - JOUR

T1 - Experimental study of the 165Ho(p,n) nuclear reaction for production of the therapeutic radioisotope 165Er

AU - Tárkányi, F.

AU - Hermanne, A.

AU - Takács, S.

AU - Ditrói, F.

AU - Király, B.

AU - Kovalev, S. F.

AU - Ignatyuk, A. V.

PY - 2008/8

Y1 - 2008/8

N2 - The 10.3 h half life radionuclide 165Er, decaying by electron capture to stable 165Ho, is an excellent candidate for Auger-electron therapy. In the frame of a systematic study of charged particle production routes of 165Er, the excitation function of the 165Ho(p,n)165Er reaction was measured up to 35 MeV by using a stacked foil irradiation technique and X-ray spectroscopy. The measured excitation function shows a significant energy shift when compared to the only experimental dataset measured earlier and an acceptable agreement with the results of different nuclear reaction model codes. The thick target yields calculated from the excitation function at typical energies available at small cyclotrons (Ep = 11 MeV and Ep = 15 MeV) are 41 MBq/μAh = 11 GBq/C and 75 MBq/μAh = 21 GBq/C, respectively.

AB - The 10.3 h half life radionuclide 165Er, decaying by electron capture to stable 165Ho, is an excellent candidate for Auger-electron therapy. In the frame of a systematic study of charged particle production routes of 165Er, the excitation function of the 165Ho(p,n)165Er reaction was measured up to 35 MeV by using a stacked foil irradiation technique and X-ray spectroscopy. The measured excitation function shows a significant energy shift when compared to the only experimental dataset measured earlier and an acceptable agreement with the results of different nuclear reaction model codes. The thick target yields calculated from the excitation function at typical energies available at small cyclotrons (Ep = 11 MeV and Ep = 15 MeV) are 41 MBq/μAh = 11 GBq/C and 75 MBq/μAh = 21 GBq/C, respectively.

KW - Cross section

KW - Excitation function

KW - Holmium target

KW - Proton irradiation

KW - Therapeutic radioisotope

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SP - 3346

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JO - Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms

JF - Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms

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