Experimental models of sepsis

N. Németh, Mihai Oltean, B. Fülesdi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Sepsis is a clinical syndrome manifesting as a complex systemic response to infection. In spite of significant developments in diagnostic, monitoring and intensive care, sepsis remains a major cause of morbidity and mortality as well as a significant economic burden. Despite inherent limitations, experimental models remain an essential tool for understanding the intricate mechanisms and pathways activated during sepsis and for developing new therapeutic approaches. However, most strategies proved as effective experimentally, have been disappointing in the clinical trials conducted so far. These unsatisfactory attempts in translating the treatment options to bedside may be attributed to the involvement of multiple mediators and pathways in sepsis with only few components being recognized and targeted but also to general or specific shortcomings of each animal model. Herein, we provide a brief overview of the pathophysiology of sepsis and concise descriptions of relevant experimental models including considerations for further refinements (i.e., animal age, gender and co-morbidities) that are further required to ensure an effective translation of the findings into the clinical setting.

Original languageEnglish
Title of host publicationAdvances in Experimental Surgery
PublisherNova Science Publishers, Inc.
Pages37-72
Number of pages36
Volume2
ISBN (Electronic)9781536127744
ISBN (Print)9781536127737
Publication statusPublished - Jan 1 2018

Fingerprint

Sepsis
Theoretical Models
Morbidity
Critical Care
Animal Models
Economics
Clinical Trials
Mortality
Therapeutics
Infection

Keywords

  • Animal models
  • Clinical versus experimental sepsis
  • Sepsis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Németh, N., Oltean, M., & Fülesdi, B. (2018). Experimental models of sepsis. In Advances in Experimental Surgery (Vol. 2, pp. 37-72). Nova Science Publishers, Inc..

Experimental models of sepsis. / Németh, N.; Oltean, Mihai; Fülesdi, B.

Advances in Experimental Surgery. Vol. 2 Nova Science Publishers, Inc., 2018. p. 37-72.

Research output: Chapter in Book/Report/Conference proceedingChapter

Németh, N, Oltean, M & Fülesdi, B 2018, Experimental models of sepsis. in Advances in Experimental Surgery. vol. 2, Nova Science Publishers, Inc., pp. 37-72.
Németh N, Oltean M, Fülesdi B. Experimental models of sepsis. In Advances in Experimental Surgery. Vol. 2. Nova Science Publishers, Inc. 2018. p. 37-72
Németh, N. ; Oltean, Mihai ; Fülesdi, B. / Experimental models of sepsis. Advances in Experimental Surgery. Vol. 2 Nova Science Publishers, Inc., 2018. pp. 37-72
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