Experimental model for use in the study of malformations caused by interaction of chemical agents used in laboratories and therapeutic drugs (toluene and acetylsalicylic-acid)

E. Tátrai, A. Hudak, G. Ungvary

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Abstract

On the 10th-13th days of pregnancy toluene (3600 mg/m3 by inhalation) and on 12th day acetylsalicylic acid (500 mg/kg of body weight per os) were administered to CFY rats and the common effect of these agents was studied. It was established that: 1) the maternal toxicity increased, i.e. increased the mortality rate, decreased the consumption of the food and the gain of weight, increased the relative weight of the liver; and 2) the foetal toxicity increased, i.e. increased the mortality rate of foetuses, the rate of the loss of the body weight, the number of the anomalies of the sternum and the incidence of the supernumerary ribs. It is believed, that the non-teratogenic toluene raises the utilization of the glycine and the level of the free salicylic-acid and consequently, the embryotoxic effect of the acetylsalicylic-acid. The danger of the occurrence of malformations as an effect of interaction of chemical agents and drugs taken in therapeutic doses is stressed.

Original languageEnglish
Pages (from-to)299-304
Number of pages6
JournalMorphologiai es igazsagugyi orvosi szemle
Volume19
Issue number4
Publication statusPublished - 1979

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Toluene
Aspirin
Theoretical Models
Body Weight
Sternum
Salicylic Acid
Mortality
Ribs
Pharmaceutical Preparations
Glycine
Inhalation
Weight Gain
Fetus
Mothers
Weights and Measures
Food
Pregnancy
Liver
Incidence
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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abstract = "On the 10th-13th days of pregnancy toluene (3600 mg/m3 by inhalation) and on 12th day acetylsalicylic acid (500 mg/kg of body weight per os) were administered to CFY rats and the common effect of these agents was studied. It was established that: 1) the maternal toxicity increased, i.e. increased the mortality rate, decreased the consumption of the food and the gain of weight, increased the relative weight of the liver; and 2) the foetal toxicity increased, i.e. increased the mortality rate of foetuses, the rate of the loss of the body weight, the number of the anomalies of the sternum and the incidence of the supernumerary ribs. It is believed, that the non-teratogenic toluene raises the utilization of the glycine and the level of the free salicylic-acid and consequently, the embryotoxic effect of the acetylsalicylic-acid. The danger of the occurrence of malformations as an effect of interaction of chemical agents and drugs taken in therapeutic doses is stressed.",
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AU - Tátrai, E.

AU - Hudak, A.

AU - Ungvary, G.

PY - 1979

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N2 - On the 10th-13th days of pregnancy toluene (3600 mg/m3 by inhalation) and on 12th day acetylsalicylic acid (500 mg/kg of body weight per os) were administered to CFY rats and the common effect of these agents was studied. It was established that: 1) the maternal toxicity increased, i.e. increased the mortality rate, decreased the consumption of the food and the gain of weight, increased the relative weight of the liver; and 2) the foetal toxicity increased, i.e. increased the mortality rate of foetuses, the rate of the loss of the body weight, the number of the anomalies of the sternum and the incidence of the supernumerary ribs. It is believed, that the non-teratogenic toluene raises the utilization of the glycine and the level of the free salicylic-acid and consequently, the embryotoxic effect of the acetylsalicylic-acid. The danger of the occurrence of malformations as an effect of interaction of chemical agents and drugs taken in therapeutic doses is stressed.

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