Experimental model for studies of continuous peritoneal dialysis in uremic rabbits

L. Gotloib, P. Crassweller, H. Rodella, D. G. Oreopoulos, G. Zellerman, R. Ogilvie, H. Husdan, L. Brandes, S. Vas

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Abstract

In this paper we described an experimental model designed for studies of continuous ambulatory peritoneal dialysis (CAPD) in uremic rabbits. We preferred the study of uremic animals because it is not known whether peritoneal membrane differs between normal and uremic animals. Animals made uremic after bilateral nephrectomy could not survive on dialysis. Instead, partial nephrectomy of one kidney and partial (5/6) destruction of the cortex of the remaining kidney by electrocauterization provided a simple and reproducible model. CAPD resulted in adequate control of uremia but the animals showed significant decreases in total plasma proteins and weight. This model is suitable for studies of the metabolic complications of CAPD.

Original languageEnglish
Pages (from-to)254-259
Number of pages6
JournalNephron
Volume31
Issue number3
Publication statusPublished - Oct 5 1982

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ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Physiology (medical)
  • Urology

Cite this

Gotloib, L., Crassweller, P., Rodella, H., Oreopoulos, D. G., Zellerman, G., Ogilvie, R., Husdan, H., Brandes, L., & Vas, S. (1982). Experimental model for studies of continuous peritoneal dialysis in uremic rabbits. Nephron, 31(3), 254-259.