Experimental investigation of preservation injury in animal kidneys after reperfusion with Euro-Collins.

N. Lázár, G. Dallos, B. Nemes, T. Németh, P. Sótónyi, L. Kóbori

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The authors evaluated the pathomorphologic alterations of removed and reperfused dog kidneys by means of light and electronmicroscopic examination. In each sample the following reversible signs were found: Hypereosinophilia (HE), Hydropic dystrophy (HD), Nuclear polymorphism (NP), Epithelial desquamation (ED), Brush border lesion (BBL), Single cell necrosis (SCN), Total tubular epithel necrosis (TTEN), Interstitial edema (IE), Perivascular edema (PE). The irreversible signs were: Basement membrane rupture (BMR), Cellular infiltration (CI), Glomerular mesangial matrix expansion (GME) and vascular lesions (VL). The most severe and mostly irreversible alterations occur in the 54-72 hours after harvesting. The authors emphasize the significance of basement membrane rupture, because the impossibility of tubular epithelial regeneration, the cellular infiltration due to its fibrogenic effect, glomerular lesion because it makes decrease the glomerular filtration rate, proceeding juxtaglomerular cell proliferation and hypertension through renin-angiotensin mechanism and vascular lesions causing renovascular hypertension and tubulopathy. The authors believe that reperfusion injury is very important factor in kidney allograft survival. Its mechanism is similar to the normal necrosis pathway, but the timing is delayed. Further investigations are needed to understand what specific alterations may occurred under blood circulation in the host to reveal more exact cause of primary graft failure after transplantation.

Original languageEnglish
Pages (from-to)192-194
Number of pages3
JournalActa Chirurgica Hungarica
Volume36
Issue number1-4
Publication statusPublished - 1997

Fingerprint

Reperfusion
Edema
Necrosis
Kidney
Basement Membrane
Blood Vessels
Rupture
Wounds and Injuries
Renovascular Hypertension
Blood Circulation
Angiotensins
Microvilli
Reperfusion Injury
Glomerular Filtration Rate
Renin
Allografts
Regeneration
Transplantation
Cell Proliferation
Dogs

ASJC Scopus subject areas

  • Surgery

Cite this

Experimental investigation of preservation injury in animal kidneys after reperfusion with Euro-Collins. / Lázár, N.; Dallos, G.; Nemes, B.; Németh, T.; Sótónyi, P.; Kóbori, L.

In: Acta Chirurgica Hungarica, Vol. 36, No. 1-4, 1997, p. 192-194.

Research output: Contribution to journalArticle

@article{41e605d81b614ecd94e8907085d27620,
title = "Experimental investigation of preservation injury in animal kidneys after reperfusion with Euro-Collins.",
abstract = "The authors evaluated the pathomorphologic alterations of removed and reperfused dog kidneys by means of light and electronmicroscopic examination. In each sample the following reversible signs were found: Hypereosinophilia (HE), Hydropic dystrophy (HD), Nuclear polymorphism (NP), Epithelial desquamation (ED), Brush border lesion (BBL), Single cell necrosis (SCN), Total tubular epithel necrosis (TTEN), Interstitial edema (IE), Perivascular edema (PE). The irreversible signs were: Basement membrane rupture (BMR), Cellular infiltration (CI), Glomerular mesangial matrix expansion (GME) and vascular lesions (VL). The most severe and mostly irreversible alterations occur in the 54-72 hours after harvesting. The authors emphasize the significance of basement membrane rupture, because the impossibility of tubular epithelial regeneration, the cellular infiltration due to its fibrogenic effect, glomerular lesion because it makes decrease the glomerular filtration rate, proceeding juxtaglomerular cell proliferation and hypertension through renin-angiotensin mechanism and vascular lesions causing renovascular hypertension and tubulopathy. The authors believe that reperfusion injury is very important factor in kidney allograft survival. Its mechanism is similar to the normal necrosis pathway, but the timing is delayed. Further investigations are needed to understand what specific alterations may occurred under blood circulation in the host to reveal more exact cause of primary graft failure after transplantation.",
author = "N. L{\'a}z{\'a}r and G. Dallos and B. Nemes and T. N{\'e}meth and P. S{\'o}t{\'o}nyi and L. K{\'o}bori",
year = "1997",
language = "English",
volume = "36",
pages = "192--194",
journal = "Magyar Sebeszet",
issn = "0025-0295",
publisher = "Ifjusagi Lapkiado Vallalat",
number = "1-4",

}

TY - JOUR

T1 - Experimental investigation of preservation injury in animal kidneys after reperfusion with Euro-Collins.

AU - Lázár, N.

AU - Dallos, G.

AU - Nemes, B.

AU - Németh, T.

AU - Sótónyi, P.

AU - Kóbori, L.

PY - 1997

Y1 - 1997

N2 - The authors evaluated the pathomorphologic alterations of removed and reperfused dog kidneys by means of light and electronmicroscopic examination. In each sample the following reversible signs were found: Hypereosinophilia (HE), Hydropic dystrophy (HD), Nuclear polymorphism (NP), Epithelial desquamation (ED), Brush border lesion (BBL), Single cell necrosis (SCN), Total tubular epithel necrosis (TTEN), Interstitial edema (IE), Perivascular edema (PE). The irreversible signs were: Basement membrane rupture (BMR), Cellular infiltration (CI), Glomerular mesangial matrix expansion (GME) and vascular lesions (VL). The most severe and mostly irreversible alterations occur in the 54-72 hours after harvesting. The authors emphasize the significance of basement membrane rupture, because the impossibility of tubular epithelial regeneration, the cellular infiltration due to its fibrogenic effect, glomerular lesion because it makes decrease the glomerular filtration rate, proceeding juxtaglomerular cell proliferation and hypertension through renin-angiotensin mechanism and vascular lesions causing renovascular hypertension and tubulopathy. The authors believe that reperfusion injury is very important factor in kidney allograft survival. Its mechanism is similar to the normal necrosis pathway, but the timing is delayed. Further investigations are needed to understand what specific alterations may occurred under blood circulation in the host to reveal more exact cause of primary graft failure after transplantation.

AB - The authors evaluated the pathomorphologic alterations of removed and reperfused dog kidneys by means of light and electronmicroscopic examination. In each sample the following reversible signs were found: Hypereosinophilia (HE), Hydropic dystrophy (HD), Nuclear polymorphism (NP), Epithelial desquamation (ED), Brush border lesion (BBL), Single cell necrosis (SCN), Total tubular epithel necrosis (TTEN), Interstitial edema (IE), Perivascular edema (PE). The irreversible signs were: Basement membrane rupture (BMR), Cellular infiltration (CI), Glomerular mesangial matrix expansion (GME) and vascular lesions (VL). The most severe and mostly irreversible alterations occur in the 54-72 hours after harvesting. The authors emphasize the significance of basement membrane rupture, because the impossibility of tubular epithelial regeneration, the cellular infiltration due to its fibrogenic effect, glomerular lesion because it makes decrease the glomerular filtration rate, proceeding juxtaglomerular cell proliferation and hypertension through renin-angiotensin mechanism and vascular lesions causing renovascular hypertension and tubulopathy. The authors believe that reperfusion injury is very important factor in kidney allograft survival. Its mechanism is similar to the normal necrosis pathway, but the timing is delayed. Further investigations are needed to understand what specific alterations may occurred under blood circulation in the host to reveal more exact cause of primary graft failure after transplantation.

UR - http://www.scopus.com/inward/record.url?scp=0031302917&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031302917&partnerID=8YFLogxK

M3 - Article

C2 - 9408343

AN - SCOPUS:0031302917

VL - 36

SP - 192

EP - 194

JO - Magyar Sebeszet

JF - Magyar Sebeszet

SN - 0025-0295

IS - 1-4

ER -