Experimental focal cerebral ischaemia in rabbits

K. Hegedüs, I. Fekete, F. Tury, L. Molnár

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

A highly reproducible form of experimental embolization of the intracranial arteries is presented in rabbits. The injection of a silver or gold ball into the internal carotid artery caused occlusion predominantly of the middle cerebral artery and/or its branches. At the moment when embolization took place, the characteristic signs of acute cerebral ischaemia occurred in the electroencephalogram, local cerebral blood flow and steady (DC) potentials. Several hours after the ball had been injected the extent of the focal lesions became recognizable on sections stained for myelin. The procedure is simple, rapid, inexpensive and practically always successful. The extent of the lesion may be influenced by the change of both the ball size and the posture of animals. Moreover, the site of occlusion is easily discernible both on radiographs and to the naked eye.

Original languageEnglish
Pages (from-to)223-230
Number of pages8
JournalJournal of Neurology
Volume232
Issue number4
DOIs
Publication statusPublished - Aug 1 1985

Keywords

  • Experimental embolism
  • Focal cerebral ischaemia
  • Rabbit
  • Silver/gold ball

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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