Kiserletes adatok az arteria renalis leszoritasat koveto erkontraktilitasi valtozasokhoz

Translated title of the contribution: Experimental data concerning investigations of contractility following the clamping of the renal artery

I. Miko, S. Csabina, M. Hauck, J. Kovacs, E. Schmidt, K. Peto, I. Furka, A. Varga, G. Toth, A. Furka

Research output: Contribution to journalArticle

Abstract

It has been well known that reperfusion following ischaemia may cause functional and structural damage not only to the organ involved but also the blood vessels supplying that organ. As in organ-sparing renal surgery it is inevitable to clamp the renal artery for some time, it is expected that reperfusion, following the lifting of clamping, causes structural changes in the vessel wall which may result in a decrease in arterial function. In our model experiments on animals, the left renal arteries were atraumatically clamped for 30, 45 and 60 minutes. Simultaneously with clamping, perfusion regional renal venous cooling was applied to some of the animals, together with nephrotomy. In some cases cooling was performed in combination with antioxidant treatment. On the 3rd postoperative day renal arteries from both sides were removed, the right, intact ones serving as control. Noradrenaline dose effect curves characterizing vessel contractility and ED50 values were determined to demonstrate functional changes. It was established that cooling the renal artery for only 30 minutes was enough to rule out the damage due to ischaemia-reperfusion. If clamping lasted for 45 minutes, venous cooling of the kidney in combination with antioxidant treatment was necessary to spare arterial function. Clamping for 60 minutes resulted in irreversible decrease in contractilily even if hypothermia and antioxidant treatment were given simultaneously.

Translated title of the contributionExperimental data concerning investigations of contractility following the clamping of the renal artery
Original languageHungarian
Pages (from-to)131-135
Number of pages5
JournalMagyar Urologia
Volume9
Issue number2
Publication statusPublished - Jan 1 1997

ASJC Scopus subject areas

  • Urology

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  • Cite this

    Miko, I., Csabina, S., Hauck, M., Kovacs, J., Schmidt, E., Peto, K., Furka, I., Varga, A., Toth, G., & Furka, A. (1997). Kiserletes adatok az arteria renalis leszoritasat koveto erkontraktilitasi valtozasokhoz. Magyar Urologia, 9(2), 131-135.