Experimental autoimmune nigral damage in guinea pigs

Wei Dong Le, J. Engelhardt, Wen Jie Xie, Larry Schneider, R. Glenn Smith, stanley H. Appel

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

An animal model of experimental autoimmune nigral damage (EAND) has been developed in guinea pigs by immunization with hybrid dopaminergic cells (MES 23.5). In such animals, loss of 40% of the substantia nigra (SN) neurons and damage to an additional 10% of SN neurons was associated with a 37-43% decrease of tyrosine hydroxylase (TH) activity and a 36% decrease of dopamine (DA) content in the nigral-striatum. Eight of the thirteen animals developed significant hypokinesia. The EAND model suggests that degeneration of dopaminergic neurons in SN can be caused by immune-mediated processes, which may help our understanding of the pathogenesis in Parkinson's disease.

Original languageEnglish
Pages (from-to)45-53
Number of pages9
JournalJournal of Neuroimmunology
Volume57
Issue number1-2
DOIs
Publication statusPublished - 1995

Fingerprint

Substantia Nigra
Guinea Pigs
Neurons
Hypokinesia
Hybrid Cells
Dopaminergic Neurons
Tyrosine 3-Monooxygenase
Parkinson Disease
Immunization
Dopamine
Animal Models

Keywords

  • Autoimmunity
  • Dopaminergic neurons
  • Parkinson's disease
  • Substantia nigra

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Neurology
  • Neurology

Cite this

Le, W. D., Engelhardt, J., Xie, W. J., Schneider, L., Smith, R. G., & Appel, S. H. (1995). Experimental autoimmune nigral damage in guinea pigs. Journal of Neuroimmunology, 57(1-2), 45-53. https://doi.org/10.1016/0165-5728(94)00160-P

Experimental autoimmune nigral damage in guinea pigs. / Le, Wei Dong; Engelhardt, J.; Xie, Wen Jie; Schneider, Larry; Smith, R. Glenn; Appel, stanley H.

In: Journal of Neuroimmunology, Vol. 57, No. 1-2, 1995, p. 45-53.

Research output: Contribution to journalArticle

Le, WD, Engelhardt, J, Xie, WJ, Schneider, L, Smith, RG & Appel, SH 1995, 'Experimental autoimmune nigral damage in guinea pigs', Journal of Neuroimmunology, vol. 57, no. 1-2, pp. 45-53. https://doi.org/10.1016/0165-5728(94)00160-P
Le, Wei Dong ; Engelhardt, J. ; Xie, Wen Jie ; Schneider, Larry ; Smith, R. Glenn ; Appel, stanley H. / Experimental autoimmune nigral damage in guinea pigs. In: Journal of Neuroimmunology. 1995 ; Vol. 57, No. 1-2. pp. 45-53.
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