Experimental autoimmune motoneuron disease

J. Engelhardt, S. H. Appel, J. M. Killian

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

An animal model of disease of the lower motoneurons has been developed by inoculating guinea pigs with bovine motoneurons. Four of 9 immunized female animals and 4 of 5 immunized male animals developed symptoms of neuromuscular degeneration marked by weakness, evidence of denervation by electromyographic and morphological criteria, and a loss of motoneurons within the spinal cord. No inflammatory foci were noted within parenchyma or meninges of the central nervous system. The immunized guinea pigs developed higher serum titers of IgG class antibodies to motoneurons. Immunohistochemical studies demonstrated the presence of IgG within spinal cord mononeurons and at the end-plates of immunized animals. This experimental autoimmune motoneuron disease may provide important insights into the cause and pathogenesis of amyotrophic lateral sclerosis, a human motoneuron disease.

Original languageEnglish
Pages (from-to)368-376
Number of pages9
JournalAnnals of Neurology
Volume26
Issue number3
Publication statusPublished - 1989

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Motor Neurons
Autoimmune Diseases
Spinal Cord
Guinea Pigs
Immunoglobulin G
Animal Disease Models
Meninges
Immunoglobulin Isotypes
Amyotrophic Lateral Sclerosis
Denervation
Central Nervous System
Serum

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Engelhardt, J., Appel, S. H., & Killian, J. M. (1989). Experimental autoimmune motoneuron disease. Annals of Neurology, 26(3), 368-376.

Experimental autoimmune motoneuron disease. / Engelhardt, J.; Appel, S. H.; Killian, J. M.

In: Annals of Neurology, Vol. 26, No. 3, 1989, p. 368-376.

Research output: Contribution to journalArticle

Engelhardt, J, Appel, SH & Killian, JM 1989, 'Experimental autoimmune motoneuron disease', Annals of Neurology, vol. 26, no. 3, pp. 368-376.
Engelhardt, J. ; Appel, S. H. ; Killian, J. M. / Experimental autoimmune motoneuron disease. In: Annals of Neurology. 1989 ; Vol. 26, No. 3. pp. 368-376.
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