Kemoterapias szer rektalis alkalmazasanak tapasztalatai 1. resz. In vitro biofarmaciai vizsgalatok; optimalis vehikulum kivalasztasa

Translated title of the contribution: Experiences with the rectal use of a chemotherapeutic agent. Part 1. In vitro biopharmaceutical examinations; selection of the optimal vehicle

Géza Regdon, István Eros, Zsuzsanna Gombköto, Judit Németh, Géza Ifj. Regdon, Ágnes Vernyik, János Sallai

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Abstract

The factors influencing in vitro liberation (Part 1) and in vivo absorption (Part 2)from trimethoprim-containing rectal suppositories and the authors' results related to them are reported in this two-part publication. Special emphasis was laid on selecting the optimal suppository base which is harmless physiologically yet not indifferent pharmacologically. From among the 24 compositions studied, a lipophilic mixture containing a surface active additive (Witepsol W 35) and a hydrophilic (Macrogolum) mixture were found to be the best in all respects. Liberation from the trimethoprim-containing rectal suppositories was measured with in vitro dynamic diffusion and spectrophotometrically. A power relation was found to exist between the quantity of the released pharmacon and the diffusion time, and a significant negative exponential relation was observed between the doses and their respective in vitro availability values.

Original languageHungarian
Pages (from-to)224-228
Number of pages5
JournalActa pharmaceutica Hungarica
Volume68
Issue number4
Publication statusPublished - Jul 1 1998

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ASJC Scopus subject areas

  • Pharmaceutical Science

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