Expected functions of salivary HSP70 in the oral cavity (Review Article)

Tibor Károly Fábián, C. Söti, Minh Tu Nguyen, P. Csermely, P. Fejérdy

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Abstract

Saliva is a major determinant of the environment on all oral surfaces in both healthy and pathological conditions. It is a body fluid, secreted by three pairs of major salivary glands and by many of minor salivary glands supplemented with several constituents originated from intact or destroyed mucosal cells, immune cells, oral microorganism and blood. Salivary Hsp70 is an important constituent of saliva, originating from several sources including salivary glands, mucosal cells, gingival crevicular fluid, blood and oral microbes. Salivary Hsp70 seems to be excreted constitutively, but its level can be increased significantly with psychological stress conditions, and also with chewing and taste stimulation. Several physiotherapeutic procedures like massage and local heat stimulation of major salivary glands also increases the amount. Expected functions of salivary Hsp70 include immunological and other antimicrobial defense mechanisms, and also cytoprotective effects on mucosal and immune cells. Consequently, it likely plays a role in healing of mucosal wounds and ulcers; in defense against gingival inflammation; in release of immune answer toward mucosal tumors; and also in allergic and autoimmune mucosal processes. Salivary Hsp70 is also likely participating in the formation of acquired pellicle on tooth and denture surfaces, leading to a possible role in physico-chemical defense of tooth surfaces; in crystal growth homeostasis of the teeth; in bacterial adhesion to tooth/denture surfaces; and in prevention and healing of denture induced mucosal irritations. However our knowledge related to salivary Hsp70 is still rather limited. Consequently the expectations about several functions detailed in this chapter are partially based on data related to extracellular but not particularly salivary Hsp70.

Original languageEnglish
Title of host publicationHeat Shock Proteins: New Research
PublisherNova Science Publishers, Inc.
Pages321-340
Number of pages20
ISBN (Print)9781604566413
Publication statusPublished - Mar 2008

Fingerprint

Dental prostheses
Mouth
Dentures
Tooth
Salivary Glands
Saliva
Blood
Mastication
Gingival Crevicular Fluid
Bacterial Adhesion
Minor Salivary Glands
Massage
Body fluids
Body Fluids
Defense Mechanisms
Crystallization
Psychological Stress
Microorganisms
Wound Healing
Ulcer

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Fábián, T. K., Söti, C., Nguyen, M. T., Csermely, P., & Fejérdy, P. (2008). Expected functions of salivary HSP70 in the oral cavity (Review Article). In Heat Shock Proteins: New Research (pp. 321-340). Nova Science Publishers, Inc..

Expected functions of salivary HSP70 in the oral cavity (Review Article). / Fábián, Tibor Károly; Söti, C.; Nguyen, Minh Tu; Csermely, P.; Fejérdy, P.

Heat Shock Proteins: New Research. Nova Science Publishers, Inc., 2008. p. 321-340.

Research output: Chapter in Book/Report/Conference proceedingChapter

Fábián, TK, Söti, C, Nguyen, MT, Csermely, P & Fejérdy, P 2008, Expected functions of salivary HSP70 in the oral cavity (Review Article). in Heat Shock Proteins: New Research. Nova Science Publishers, Inc., pp. 321-340.
Fábián TK, Söti C, Nguyen MT, Csermely P, Fejérdy P. Expected functions of salivary HSP70 in the oral cavity (Review Article). In Heat Shock Proteins: New Research. Nova Science Publishers, Inc. 2008. p. 321-340
Fábián, Tibor Károly ; Söti, C. ; Nguyen, Minh Tu ; Csermely, P. ; Fejérdy, P. / Expected functions of salivary HSP70 in the oral cavity (Review Article). Heat Shock Proteins: New Research. Nova Science Publishers, Inc., 2008. pp. 321-340
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