Aim: The side effects of the drugs are partly of non-specific origin (nocebo-effect). Perceptual characteristics of curatives (colour, size, etc.) and certain personality characteristics may be important determining factors of these effects. In this study, the relationships between these factors and the expected side effects were investigated. Methods: The participants (118 undergraduate university students) were asked to rate the estimated probability of occurrence of ten non-specific side effects for six different looking tablets, and to fill out several personality questionnaires (STAI-T, LOT-R, PHQ-15, SSAS). Results: Significant differences among the tablets were found for every side effect. Good predictors of the expected severity of side effects were the somatisation tendency (PHQ-15) and the somatosensory amplification (SSAS). According to the path-analysis, trait-anxiety and gender had only indirect effects (via PHQ-15 and SSAS) upon the expected severity of side effects, and dispositional optimism had no effect at all. Discussion: The look-and-feel of a given curative can evoke a specific pattern of non-specific side effects, while personality characteristics have an impact upon the expected severity of these effects. Non-specific side-effects can influence medication in multiple ways: e.g. via decreasing compliance or amplifying specific side effects (interaction). These factors should be taken into account when deciding the look-and-feel of curatives (intelligent medicine designing).
|Translated title of the contribution||Expectations of side effects evoked by perceptual characteristics of curatives and their psychological background|
|Number of pages||16|
|Journal||Mentalhigiene es Pszichoszomatika|
|Publication status||Published - Mar 1 2009|
ASJC Scopus subject areas
- Neuropsychology and Physiological Psychology
- Psychiatry and Mental health