Expansion of CD4 phenotype among CD160 receptor-expressing lymphocytes in murine pregnancy

Matyas Meggyes, L. Szereday, Pal Jakso, Barbara Bogar, Agnes Bogdan, Jasper Nörenberg, Eva Miko, A. Barakonyi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Problem: CD160, a cell surface co-receptor, is capable of up- or downregulating cell proliferation, cytotoxicity or cytokine production on lymphocytes. Our aim was to investigate CD160+ lymphocytes in the periphery and at the maternal-foetal interface during murine pregnancy. Method of study: CD4+, CD8+ and gamma/delta T-cell phenotype, TIM3 co-expression and cytotoxic activity of CD160+ lymphocytes of pregnant BALB/c mice were analysed by flow cytometry. Results: The percentage of CD160+ lymphocytes in the decidua was unchanged compared to non-pregnant endometrium; however, the ratio of CD4+ cells within the CD160 population was significantly increased. The co-expression of TIM3 co-inhibitory molecule and cytotoxicity of CD160+ cells were increased in the decidua. Conclusion: The expansion of CD4-expressing CD160+ decidual lymphocytes is a new observation suggesting a potential regulatory role of T-cell function during mouse pregnancy. The altered immunological character of CD160+ lymphocytes could play a role in the maintenance of murine pregnancy.

Original languageEnglish
Article numbere12745
JournalAmerican Journal of Reproductive Immunology
Volume78
Issue number6
DOIs
Publication statusPublished - Dec 1 2017

Keywords

  • CD160 receptor
  • cytotoxicity
  • murine pregnancy
  • T cells
  • TIM3

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynaecology

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