Expanding the DNA alphabet in the fruit fly: Uracil enrichment in genomic DNA

András Horváth, Angéla Békési, Villõ Muha, Miklós Erdélyi, Beáta G. Vértessy

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

DNA integrity is under the control of multiple pathways of nucleotide metabolism and DNA damage recognition and repair. Unusual sets of protein factors involved in these control mechanisms may result in tolerance and accumulation of non-canonical bases within the DNA. We investigate the presence of uracil in genomic DNA of Drosophila melanogaster. Results indicate a developmental pattern and strong correlations between uracil-DNA levels, dUTPase expression and developmental fate of different tissues. The intriguing lack of the catalytically most efficient uracil-DNA glycosylase in Drosophila melanogaster may be a general attribute of Holometabola and is suggested to be involved in the specific characteristics of uracil-DNA metabolism in these insects.

Original languageEnglish
JournalFly
Volume7
Issue number1
Publication statusPublished - 2013

Keywords

  • Metamorphosis
  • Pupating insect
  • Tissue-specific
  • Uracil
  • dUTPase

ASJC Scopus subject areas

  • Insect Science

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