Exosomes

Potential model for complement-stealth delivery systems

Gergely Milosevits, J. Szebeni, Silke Krol

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Exosomes are nature's nanocarriers that transport biological information in humans. Their structural properties, origin and functions are making them interesting objects for the diagnosis of diseases, such as cancer, and also, as innovative tools for drug delivery. The interaction of exosomes with the immune system has been one of the focal points of interest; nevertheless their "stealth" properties helping to avoid adverse immune reactions are still not fully understood. In this review, after giving an overview of recent findings on the role of exosomes in disease pathogenesis and physiological functions, we focused on their interaction with the immune system and possibilities for clinical applications. The potential of exosomes of creating stealth nanoparticles that are better tolerated by the immune system than the presently available synthetic drug delivery systems represent a promising new approach in nanomedicine.

Original languageEnglish
Pages (from-to)207-218
Number of pages12
JournalEuropean Journal of Nanomedicine
Volume7
Issue number3
DOIs
Publication statusPublished - Jun 1 2015

Fingerprint

Exosomes
immune systems
Immune system
complement
delivery
Immune System
drugs
Antigen-antibody reactions
Medical nanotechnology
pathogenesis
Biological Transport
Nanomedicine
Drug delivery
Structural properties
Drug Delivery Systems
cancer
interactions
Nanoparticles
nanoparticles
Pharmaceutical Preparations

Keywords

  • complement
  • drug delivery
  • exosome
  • liposome
  • nanocarrier

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Physical and Theoretical Chemistry
  • Biomedical Engineering

Cite this

Exosomes : Potential model for complement-stealth delivery systems. / Milosevits, Gergely; Szebeni, J.; Krol, Silke.

In: European Journal of Nanomedicine, Vol. 7, No. 3, 01.06.2015, p. 207-218.

Research output: Contribution to journalArticle

Milosevits, Gergely ; Szebeni, J. ; Krol, Silke. / Exosomes : Potential model for complement-stealth delivery systems. In: European Journal of Nanomedicine. 2015 ; Vol. 7, No. 3. pp. 207-218.
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