Exosomal long non-coding RNAs as biomarkers in human diseases

Evelyn Kelemen, Judit Danis, Anikó Göblös, Z. Bata-Csörgő, M. Széll

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The intensive study of extracellular vesicles was started about a decade ago revealing alterations of their amount and content to several cellular stimuli, highly depending on the releasing cell type. Exosomes, a type of extracellular vesicles, are released by every cell type and are present in most body fluids, what makes them attractive targets of biomarker research. Several studies have indicated that their content - including proteins and coding, as well as non-coding nucleic acids - could represent the disease state and serves as specific disease biomarkers. Out of these molecules, a special interest was gained by long noncoding RNAs (lncRNAs). Just as exosomes, lncRNAs are specific to their cell of origin and often specific to diseases, also found extracellularly, mainly contained in extracellular vesicles. Thus, recent efforts in biomarker research has turned to circulating exosomal lncRNAs, which might lead to the development of highly specific disease markers. Here we summarize the current knowledge on disease-associated exosomal long non-coding RNAs. The intensive studies in this area have revealed numerous potential targets for biomarkers, and highlighted the potential of their combination with other exosomal markers to represent a highly sensitive and specific diagnostic tool. However, we believe that additional functional data on both exosomes and lncRNAs are necessary for understanding their deregulation in diseases and developing their use as diagnostic approaches.

Original languageEnglish
Pages (from-to)224-236
Number of pages13
JournalElectronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine
Volume30
Issue number2
Publication statusPublished - Jan 1 2019

Fingerprint

Long Noncoding RNA
Biomarkers
Exosomes
Deregulation
Body fluids
Body Fluids
Research
Nucleic Acids
Molecules
Extracellular Vesicles

Keywords

  • Cancer
  • Chronic kidney disease
  • Exosomes
  • Long non-coding RNAs
  • Psoriasis

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Exosomal long non-coding RNAs as biomarkers in human diseases. / Kelemen, Evelyn; Danis, Judit; Göblös, Anikó; Bata-Csörgő, Z.; Széll, M.

In: Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine, Vol. 30, No. 2, 01.01.2019, p. 224-236.

Research output: Contribution to journalArticle

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