Exogenous and endogenous stimulations during different phases of pancreatic secretion in conscious rats

A. Pap, P. Lechene de la Porte, H. Sarles

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The effects of stepwise increasing doses of intravenous caerulein, secretin, urecholine and intraduodenal oleic acid were investigated in conscious rats. a) Basal water, bicarbonate, and protein secretion significantly augmented after diversion of pancreatic juice. On the basis of protein secretory pattern of basal secretion 3 stable stages have been recognised: 1. The most physiological basal stage during return of pancreatic juice. 2. The first, highly elevated plateau from the 4th to 7th 30-min period after diversion of pancreatic juice. 3. The second, delayed and less elevated plateau after 270 min. b) The folowing patterns of stimulated secretion were observed: 1. Caerulein stimulated protein and bicarbonate secretion during return of juice and the first plateau but it failed to elicit a significant response during the second, delayed plateau. 2. Secretin and urecholine showed similar protein responses during return of pancreatic juice but after diversion, they stimulated water and bicarbonate secretion only. 3. During the second plateau oleic acid stimulation resulted in a significant increase in water and bicarbonate secretion but no significant increase occured in protein output. The delayed inhibition of protein secretion, previously described in our laboratory, was unchanged. 4. Supramaximal doses of exogenous stimuli caused an inhibition in pancreatic secretion.

Original languageEnglish
Pages (from-to)19-27
Number of pages9
JournalPflugers Archiv European Journal of Physiology
Volume383
Issue number1
DOIs
Publication statusPublished - Dec 1979

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Rats
Pancreatic Juice
Bicarbonates
Bethanechol
Ceruletide
Proteins
Secretin
Oleic Acid
Water

Keywords

  • Biphasic responses
  • Diversion of pancreatic juice
  • Exogenous and endogenous stimulation
  • Water, bicarbonate and protein secretion

ASJC Scopus subject areas

  • Physiology

Cite this

Exogenous and endogenous stimulations during different phases of pancreatic secretion in conscious rats. / Pap, A.; de la Porte, P. Lechene; Sarles, H.

In: Pflugers Archiv European Journal of Physiology, Vol. 383, No. 1, 12.1979, p. 19-27.

Research output: Contribution to journalArticle

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