Exocrine pancreatic secretion: effect of subarachnoidal application of cholecystokinin octapeptide in rats

Sándor Ormai, Lajos Korányi, Mária Sasvári, Elemér Endröczi

Research output: Contribution to journalArticle

Abstract

Administration of cholecystokinin octapeptide (CCK-8) intravenously, or in the subarachnoidal surface of the olfactory lobe in rats, caused an increase in pancreatic protein and amylase secretion. It was observed that for subarachnoidal administration of CCK-8 both protein and amylase outputs were higher than that seen after i.v. injection. This result is consistent with the presence of central CCK receptors which when activated can enhance pancreatic exocrine secretion. The blockade of the effect of CCK by administration of CCK-8-specific antisera proves the specificity of the subarachnoidal CCK-8 stimulation.

Original languageEnglish
Pages (from-to)51-55
Number of pages5
JournalRegulatory Peptides
Volume23
Issue number1
DOIs
Publication statusPublished - Oct 1988

Keywords

  • Brain receptor
  • Cholecystokinin octapeptide
  • Conscious rat
  • Pancreatic secretion

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Clinical Biochemistry
  • Cellular and Molecular Neuroscience

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