Exocrine pancreatic secretion: effect of subarachnoidal application of cholecystokinin octapeptide in rats

Sándor Ormai, Lajos Korányi, M. Sasvári, Elemér Endröczi

Research output: Contribution to journalArticle

Abstract

Administration of cholecystokinin octapeptide (CCK-8) intravenously, or in the subarachnoidal surface of the olfactory lobe in rats, caused an increase in pancreatic protein and amylase secretion. It was observed that for subarachnoidal administration of CCK-8 both protein and amylase outputs were higher than that seen after i.v. injection. This result is consistent with the presence of central CCK receptors which when activated can enhance pancreatic exocrine secretion. The blockade of the effect of CCK by administration of CCK-8-specific antisera proves the specificity of the subarachnoidal CCK-8 stimulation.

Original languageEnglish
Pages (from-to)51-55
Number of pages5
JournalRegulatory Peptides
Volume23
Issue number1
DOIs
Publication statusPublished - 1988

Fingerprint

Sincalide
Rats
Amylases
Cholecystokinin Receptors
Immune Sera
Proteins
Injections

Keywords

  • Brain receptor
  • Cholecystokinin octapeptide
  • Conscious rat
  • Pancreatic secretion

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Neuroscience(all)

Cite this

Exocrine pancreatic secretion : effect of subarachnoidal application of cholecystokinin octapeptide in rats. / Ormai, Sándor; Korányi, Lajos; Sasvári, M.; Endröczi, Elemér.

In: Regulatory Peptides, Vol. 23, No. 1, 1988, p. 51-55.

Research output: Contribution to journalArticle

Ormai, Sándor ; Korányi, Lajos ; Sasvári, M. ; Endröczi, Elemér. / Exocrine pancreatic secretion : effect of subarachnoidal application of cholecystokinin octapeptide in rats. In: Regulatory Peptides. 1988 ; Vol. 23, No. 1. pp. 51-55.
@article{a911fa18b6b3486e9f437cbde66798c0,
title = "Exocrine pancreatic secretion: effect of subarachnoidal application of cholecystokinin octapeptide in rats",
abstract = "Administration of cholecystokinin octapeptide (CCK-8) intravenously, or in the subarachnoidal surface of the olfactory lobe in rats, caused an increase in pancreatic protein and amylase secretion. It was observed that for subarachnoidal administration of CCK-8 both protein and amylase outputs were higher than that seen after i.v. injection. This result is consistent with the presence of central CCK receptors which when activated can enhance pancreatic exocrine secretion. The blockade of the effect of CCK by administration of CCK-8-specific antisera proves the specificity of the subarachnoidal CCK-8 stimulation.",
keywords = "Brain receptor, Cholecystokinin octapeptide, Conscious rat, Pancreatic secretion",
author = "S{\'a}ndor Ormai and Lajos Kor{\'a}nyi and M. Sasv{\'a}ri and Elem{\'e}r Endr{\"o}czi",
year = "1988",
doi = "10.1016/0167-0115(88)90420-X",
language = "English",
volume = "23",
pages = "51--55",
journal = "Regulatory Peptides",
issn = "0167-0115",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Exocrine pancreatic secretion

T2 - effect of subarachnoidal application of cholecystokinin octapeptide in rats

AU - Ormai, Sándor

AU - Korányi, Lajos

AU - Sasvári, M.

AU - Endröczi, Elemér

PY - 1988

Y1 - 1988

N2 - Administration of cholecystokinin octapeptide (CCK-8) intravenously, or in the subarachnoidal surface of the olfactory lobe in rats, caused an increase in pancreatic protein and amylase secretion. It was observed that for subarachnoidal administration of CCK-8 both protein and amylase outputs were higher than that seen after i.v. injection. This result is consistent with the presence of central CCK receptors which when activated can enhance pancreatic exocrine secretion. The blockade of the effect of CCK by administration of CCK-8-specific antisera proves the specificity of the subarachnoidal CCK-8 stimulation.

AB - Administration of cholecystokinin octapeptide (CCK-8) intravenously, or in the subarachnoidal surface of the olfactory lobe in rats, caused an increase in pancreatic protein and amylase secretion. It was observed that for subarachnoidal administration of CCK-8 both protein and amylase outputs were higher than that seen after i.v. injection. This result is consistent with the presence of central CCK receptors which when activated can enhance pancreatic exocrine secretion. The blockade of the effect of CCK by administration of CCK-8-specific antisera proves the specificity of the subarachnoidal CCK-8 stimulation.

KW - Brain receptor

KW - Cholecystokinin octapeptide

KW - Conscious rat

KW - Pancreatic secretion

UR - http://www.scopus.com/inward/record.url?scp=0024237836&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024237836&partnerID=8YFLogxK

U2 - 10.1016/0167-0115(88)90420-X

DO - 10.1016/0167-0115(88)90420-X

M3 - Article

C2 - 2467329

AN - SCOPUS:0024237836

VL - 23

SP - 51

EP - 55

JO - Regulatory Peptides

JF - Regulatory Peptides

SN - 0167-0115

IS - 1

ER -