Exhaled carbon monoxide concentration increases after exercise in children with cystic fibrosis

I. Horváth, P. Borka, P. Apor, M. Kollai

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Oxidative stress and hypoxia, which may occur in cystic fibrosis patients (CF) at rest and may be worsened by exercise, induce the expression of heme oxygenase (HO)-I, resulting in increased carbon monoxide (CO) formation. We tested that exhaled CO level (eCO) was higher in CF patients than in healthy subjects, and that exercise increased CO production. Exhaled CO was measured electrochemically in 15 CF patients and 15 control subjects at rest (T0), immediately (T1) and 60 minutes after a symptom-limited incremental bicycle exercise test (T60). Arterial oxygen saturation (TcO2) was monitored transcutaneously. Data are given as mean±SEM. Baseline eCO was 1.90±0.26 ppm in the control and 1.93±0.27 ppm in the CF group. In both groups eCO was lower at T1 than at rest. In the control group eCO was also low at T60, but in the CF group it was increased compared to baseline level at this timepoint. Exercise caused oxyhemoglobin desaturation in CF patients which was related to the increase in eCO measured at T60 (r=-0.67, p

Original languageEnglish
Pages (from-to)237-244
Number of pages8
JournalActa Physiologica Hungarica
Volume86
Issue number3-4
Publication statusPublished - 1999

Fingerprint

Carbon Monoxide
Cystic Fibrosis
Exercise
Heme Oxygenase (Decyclizing)
Oxyhemoglobins
Exercise Test
Healthy Volunteers
Oxidative Stress
Oxygen
Control Groups

Keywords

  • Cystic fibrosis
  • Exercise
  • Exhaled carbon monoxide
  • Heme oxygenase-1
  • Hypoxia
  • Inflammation
  • Oxidative stress

ASJC Scopus subject areas

  • Physiology

Cite this

Exhaled carbon monoxide concentration increases after exercise in children with cystic fibrosis. / Horváth, I.; Borka, P.; Apor, P.; Kollai, M.

In: Acta Physiologica Hungarica, Vol. 86, No. 3-4, 1999, p. 237-244.

Research output: Contribution to journalArticle

@article{7c390d23e1be4533b99580c7ea50ff8d,
title = "Exhaled carbon monoxide concentration increases after exercise in children with cystic fibrosis",
abstract = "Oxidative stress and hypoxia, which may occur in cystic fibrosis patients (CF) at rest and may be worsened by exercise, induce the expression of heme oxygenase (HO)-I, resulting in increased carbon monoxide (CO) formation. We tested that exhaled CO level (eCO) was higher in CF patients than in healthy subjects, and that exercise increased CO production. Exhaled CO was measured electrochemically in 15 CF patients and 15 control subjects at rest (T0), immediately (T1) and 60 minutes after a symptom-limited incremental bicycle exercise test (T60). Arterial oxygen saturation (TcO2) was monitored transcutaneously. Data are given as mean±SEM. Baseline eCO was 1.90±0.26 ppm in the control and 1.93±0.27 ppm in the CF group. In both groups eCO was lower at T1 than at rest. In the control group eCO was also low at T60, but in the CF group it was increased compared to baseline level at this timepoint. Exercise caused oxyhemoglobin desaturation in CF patients which was related to the increase in eCO measured at T60 (r=-0.67, p",
keywords = "Cystic fibrosis, Exercise, Exhaled carbon monoxide, Heme oxygenase-1, Hypoxia, Inflammation, Oxidative stress",
author = "I. Horv{\'a}th and P. Borka and P. Apor and M. Kollai",
year = "1999",
language = "English",
volume = "86",
pages = "237--244",
journal = "Physiology International",
issn = "2498-602X",
publisher = "Akademiai Kiado",
number = "3-4",

}

TY - JOUR

T1 - Exhaled carbon monoxide concentration increases after exercise in children with cystic fibrosis

AU - Horváth, I.

AU - Borka, P.

AU - Apor, P.

AU - Kollai, M.

PY - 1999

Y1 - 1999

N2 - Oxidative stress and hypoxia, which may occur in cystic fibrosis patients (CF) at rest and may be worsened by exercise, induce the expression of heme oxygenase (HO)-I, resulting in increased carbon monoxide (CO) formation. We tested that exhaled CO level (eCO) was higher in CF patients than in healthy subjects, and that exercise increased CO production. Exhaled CO was measured electrochemically in 15 CF patients and 15 control subjects at rest (T0), immediately (T1) and 60 minutes after a symptom-limited incremental bicycle exercise test (T60). Arterial oxygen saturation (TcO2) was monitored transcutaneously. Data are given as mean±SEM. Baseline eCO was 1.90±0.26 ppm in the control and 1.93±0.27 ppm in the CF group. In both groups eCO was lower at T1 than at rest. In the control group eCO was also low at T60, but in the CF group it was increased compared to baseline level at this timepoint. Exercise caused oxyhemoglobin desaturation in CF patients which was related to the increase in eCO measured at T60 (r=-0.67, p

AB - Oxidative stress and hypoxia, which may occur in cystic fibrosis patients (CF) at rest and may be worsened by exercise, induce the expression of heme oxygenase (HO)-I, resulting in increased carbon monoxide (CO) formation. We tested that exhaled CO level (eCO) was higher in CF patients than in healthy subjects, and that exercise increased CO production. Exhaled CO was measured electrochemically in 15 CF patients and 15 control subjects at rest (T0), immediately (T1) and 60 minutes after a symptom-limited incremental bicycle exercise test (T60). Arterial oxygen saturation (TcO2) was monitored transcutaneously. Data are given as mean±SEM. Baseline eCO was 1.90±0.26 ppm in the control and 1.93±0.27 ppm in the CF group. In both groups eCO was lower at T1 than at rest. In the control group eCO was also low at T60, but in the CF group it was increased compared to baseline level at this timepoint. Exercise caused oxyhemoglobin desaturation in CF patients which was related to the increase in eCO measured at T60 (r=-0.67, p

KW - Cystic fibrosis

KW - Exercise

KW - Exhaled carbon monoxide

KW - Heme oxygenase-1

KW - Hypoxia

KW - Inflammation

KW - Oxidative stress

UR - http://www.scopus.com/inward/record.url?scp=0033288508&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033288508&partnerID=8YFLogxK

M3 - Article

C2 - 10943654

AN - SCOPUS:0033288508

VL - 86

SP - 237

EP - 244

JO - Physiology International

JF - Physiology International

SN - 2498-602X

IS - 3-4

ER -