Exhaled breath condensate pH in patients with cystic fibrosis

B. Antus, I. Barta, E. Csiszér, Krisztina Kelemen

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objective and design: Exhaled breath condensate (EBC) pH has been proposed as a useful, non-invasive marker of airway inflammation in pulmonary diseases. In this study we tested whether cystic fibrosis (CF) is associated with acidification of EBC, when pH is assessed by the CO2 gas standardization method. Methods: EBC was collected using two different devices (EcoScreen and R-Tube) in 46 stable CF patients during routine clinical visits and in 28 healthy controls. Results: Mean EBC pH in CF patients and in healthy controls was similar (EcoScreen: CF patients: 6.38 ± 0.03 versus controls: 6.39 ± 0.03, p = 0.699; R-tube: CF patients: 5.94 ± 0.04 versus controls: 6.02 ± 0.03, p = 0.159). Inflammatory cell counts in spontaneously expectorated sputum obtained in a subset of patients (n = 20) showed no correlation with pH values. EBC samples collected with the R-tube were more acidic than those collected with the EcoScreen device (p

Original languageEnglish
Pages (from-to)1141-1147
Number of pages7
JournalInflammation Research
Volume61
Issue number10
DOIs
Publication statusPublished - Oct 2012

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Cystic Fibrosis
Equipment and Supplies
Sputum
Lung Diseases
Cell Count
Gases
Inflammation

Keywords

  • Biomarker
  • Cystic fibrosis
  • Exhaled breath condensate
  • Inflammation
  • pH

ASJC Scopus subject areas

  • Pharmacology
  • Immunology

Cite this

Exhaled breath condensate pH in patients with cystic fibrosis. / Antus, B.; Barta, I.; Csiszér, E.; Kelemen, Krisztina.

In: Inflammation Research, Vol. 61, No. 10, 10.2012, p. 1141-1147.

Research output: Contribution to journalArticle

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