Exhaled breath condensate pH in lung transplant recipients with bronchiolitis obliterans syndrome

Szabolcs Soter, Krisztina Kelemen, I. Barta, Marta Valyon, E. Csiszér, B. Antus

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: Assessment of exhaled breath condensate (EBC) pH is a promising method for investigating airway pathology. However, inaccurate measurement techniques may bias pH readings. In this longitudinal study, we tested whether development of bronchiolitis obliterans syndrome (BOS) in lung transplant recipients is associated with acidification of EBC. METHODS.: EBC was collected in 15 patients with BOS and 16 stable BOS-free patients during routine clinical visits. From nine BOS patients, samples were collected before and after the onset of BOS, as well. Twenty healthy nontransplant subjects served as controls. EBC pH was measured by the carbon dioxide gas standardization method. Results: EBC pH in patients with and without BOS and controls was similar (BOS group: 6.40±0.04, BOS-free group: 6.45±0.03; controls: 6.39±0.02; P>0.05). In patients who developed BOS during the follow-up, EBC pH before and after the onset of BOS was comparable (pre-BOS: 6.41±0.04 vs. post-BOS: 6.41±0.04; P>0.05). Coefficient of variation for repeated pH measurements in controls and subjects with and without BOS was 2.3%±0.3%, 2.0%±0.3%, and 1.7%±0.2%, respectively (P>0.05). Similarly, the limits of agreement for between-visit variability determined by the Bland-Altman test were comparable among the study groups. Conclusions: These data suggest that assessment of EBC pH is of limited value for the diagnosis of BOS.

Original languageEnglish
Pages (from-to)793-797
Number of pages5
JournalTransplantation
Volume91
Issue number7
DOIs
Publication statusPublished - Apr 15 2011

Fingerprint

Bronchiolitis Obliterans
Lung
Transplant Recipients
Carbon Dioxide

Keywords

  • Biomarker
  • Breath condensate
  • Bronchiolitis obliterans syndrome
  • Lung
  • pH
  • Variability

ASJC Scopus subject areas

  • Transplantation

Cite this

Exhaled breath condensate pH in lung transplant recipients with bronchiolitis obliterans syndrome. / Soter, Szabolcs; Kelemen, Krisztina; Barta, I.; Valyon, Marta; Csiszér, E.; Antus, B.

In: Transplantation, Vol. 91, No. 7, 15.04.2011, p. 793-797.

Research output: Contribution to journalArticle

@article{7b6ff4f6e8c647569e996a4e76efe3e2,
title = "Exhaled breath condensate pH in lung transplant recipients with bronchiolitis obliterans syndrome",
abstract = "Background: Assessment of exhaled breath condensate (EBC) pH is a promising method for investigating airway pathology. However, inaccurate measurement techniques may bias pH readings. In this longitudinal study, we tested whether development of bronchiolitis obliterans syndrome (BOS) in lung transplant recipients is associated with acidification of EBC. METHODS.: EBC was collected in 15 patients with BOS and 16 stable BOS-free patients during routine clinical visits. From nine BOS patients, samples were collected before and after the onset of BOS, as well. Twenty healthy nontransplant subjects served as controls. EBC pH was measured by the carbon dioxide gas standardization method. Results: EBC pH in patients with and without BOS and controls was similar (BOS group: 6.40±0.04, BOS-free group: 6.45±0.03; controls: 6.39±0.02; P>0.05). In patients who developed BOS during the follow-up, EBC pH before and after the onset of BOS was comparable (pre-BOS: 6.41±0.04 vs. post-BOS: 6.41±0.04; P>0.05). Coefficient of variation for repeated pH measurements in controls and subjects with and without BOS was 2.3{\%}±0.3{\%}, 2.0{\%}±0.3{\%}, and 1.7{\%}±0.2{\%}, respectively (P>0.05). Similarly, the limits of agreement for between-visit variability determined by the Bland-Altman test were comparable among the study groups. Conclusions: These data suggest that assessment of EBC pH is of limited value for the diagnosis of BOS.",
keywords = "Biomarker, Breath condensate, Bronchiolitis obliterans syndrome, Lung, pH, Variability",
author = "Szabolcs Soter and Krisztina Kelemen and I. Barta and Marta Valyon and E. Csisz{\'e}r and B. Antus",
year = "2011",
month = "4",
day = "15",
doi = "10.1097/TP.0b013e31820d3bc3",
language = "English",
volume = "91",
pages = "793--797",
journal = "Transplantation",
issn = "0041-1337",
publisher = "Lippincott Williams and Wilkins",
number = "7",

}

TY - JOUR

T1 - Exhaled breath condensate pH in lung transplant recipients with bronchiolitis obliterans syndrome

AU - Soter, Szabolcs

AU - Kelemen, Krisztina

AU - Barta, I.

AU - Valyon, Marta

AU - Csiszér, E.

AU - Antus, B.

PY - 2011/4/15

Y1 - 2011/4/15

N2 - Background: Assessment of exhaled breath condensate (EBC) pH is a promising method for investigating airway pathology. However, inaccurate measurement techniques may bias pH readings. In this longitudinal study, we tested whether development of bronchiolitis obliterans syndrome (BOS) in lung transplant recipients is associated with acidification of EBC. METHODS.: EBC was collected in 15 patients with BOS and 16 stable BOS-free patients during routine clinical visits. From nine BOS patients, samples were collected before and after the onset of BOS, as well. Twenty healthy nontransplant subjects served as controls. EBC pH was measured by the carbon dioxide gas standardization method. Results: EBC pH in patients with and without BOS and controls was similar (BOS group: 6.40±0.04, BOS-free group: 6.45±0.03; controls: 6.39±0.02; P>0.05). In patients who developed BOS during the follow-up, EBC pH before and after the onset of BOS was comparable (pre-BOS: 6.41±0.04 vs. post-BOS: 6.41±0.04; P>0.05). Coefficient of variation for repeated pH measurements in controls and subjects with and without BOS was 2.3%±0.3%, 2.0%±0.3%, and 1.7%±0.2%, respectively (P>0.05). Similarly, the limits of agreement for between-visit variability determined by the Bland-Altman test were comparable among the study groups. Conclusions: These data suggest that assessment of EBC pH is of limited value for the diagnosis of BOS.

AB - Background: Assessment of exhaled breath condensate (EBC) pH is a promising method for investigating airway pathology. However, inaccurate measurement techniques may bias pH readings. In this longitudinal study, we tested whether development of bronchiolitis obliterans syndrome (BOS) in lung transplant recipients is associated with acidification of EBC. METHODS.: EBC was collected in 15 patients with BOS and 16 stable BOS-free patients during routine clinical visits. From nine BOS patients, samples were collected before and after the onset of BOS, as well. Twenty healthy nontransplant subjects served as controls. EBC pH was measured by the carbon dioxide gas standardization method. Results: EBC pH in patients with and without BOS and controls was similar (BOS group: 6.40±0.04, BOS-free group: 6.45±0.03; controls: 6.39±0.02; P>0.05). In patients who developed BOS during the follow-up, EBC pH before and after the onset of BOS was comparable (pre-BOS: 6.41±0.04 vs. post-BOS: 6.41±0.04; P>0.05). Coefficient of variation for repeated pH measurements in controls and subjects with and without BOS was 2.3%±0.3%, 2.0%±0.3%, and 1.7%±0.2%, respectively (P>0.05). Similarly, the limits of agreement for between-visit variability determined by the Bland-Altman test were comparable among the study groups. Conclusions: These data suggest that assessment of EBC pH is of limited value for the diagnosis of BOS.

KW - Biomarker

KW - Breath condensate

KW - Bronchiolitis obliterans syndrome

KW - Lung

KW - pH

KW - Variability

UR - http://www.scopus.com/inward/record.url?scp=79954924251&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79954924251&partnerID=8YFLogxK

U2 - 10.1097/TP.0b013e31820d3bc3

DO - 10.1097/TP.0b013e31820d3bc3

M3 - Article

VL - 91

SP - 793

EP - 797

JO - Transplantation

JF - Transplantation

SN - 0041-1337

IS - 7

ER -