Exhaled breath condensate in disease monitoring

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Collection of exhaled breath condensate (EBC) is a simple, noninvasive way of obtaining samples from the airways. EBC contains a large number of mediators including adenosine, ammonia, hydrogen peroxide, ions, isoprostanes, leukotrienes, nitric oxide-derived products, prostaglandins, etc. Levels of these mediators are influenced by airway diseases, including asthma, chronic obstructive airway diseases (COPD), cystic fibrosis (CF), and bronchiectasis, and modulated by treatment modalities. Furthermore, EBC has other characteristics, such as pH, which is also modulated in airway diseases in relation to disease activity. Although analysis of EBC is a research tool at present, there is accumulating evidence suggesting that detecting and monitoring of biomarkers in EBC may be helpful in diagnosis and follow-up of patients with various pulmonary diseases, not only in research but also in clinical practice. The aim of this review is to describe the most important methodological issues and summarize our current knowledge on the use of EBC analysis for monitoring lung diseases.

Original languageEnglish
Pages (from-to)195-200
Number of pages6
JournalClinical Pulmonary Medicine
Volume10
Issue number4
Publication statusPublished - Jul 1 2003

Keywords

  • Airway inflammation
  • Asthma
  • Exhaled breath condensate
  • Noninvasive monitoring
  • Oxidative stress

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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