Exhaled biomarker pattern is altered in children with obstructive sleep apnoea syndrome

Pálma Benedek, Zsófia Lázár, András Bikov, László Kunos, Gábor Katona, I. Horváth

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Objectives: Obstructive sleep apnoea syndrome (OSAS) is a common disorder in children, which is associated with enhanced inflammatory status. Inflammation-associated changes could be monitored by the assessment of exhaled biomarker profile. This study aimed to compare the exhaled biomarker profile in children with OSAS and habitual snorers. Methods: Eighteen children with OSAS (8 ± 2 years, mean ± SD) and ten non-OSAS subjects with habitual snoring (9 ± 2 years) were recruited. Exhaled breath was collected from the lower airways, processed using an electronic nose (E-nose) and analyzed off-line using principal component analysis, followed by discrimination analysis and logistic regression to build a receiver operating characteristic (ROC) curve. Results: Exhaled biomarker pattern of OSAS patients was discriminated from that of control subjects (p=0.03, cross-validation accuracy: 64%), ROC curve analysis (area: 0.83) showed 78% sensitivity and 70% specificity. Conclusions: The altered exhaled biomarker pattern in OSAS might reflect accelerated airway and/or systemic inflammation in diseased state. Breath pattern analysis by an E-nose can serve as a new tool to monitor inflammation in children with OSAS.

Original languageEnglish
Pages (from-to)1244-1247
Number of pages4
JournalInternational Journal of Pediatric Otorhinolaryngology
Volume77
Issue number8
DOIs
Publication statusPublished - Aug 2013

Fingerprint

Obstructive Sleep Apnea
Biomarkers
Electronic Nose
Inflammation
ROC Curve
Snoring
Sleep Apnea Syndromes
Principal Component Analysis
Logistic Models
Sensitivity and Specificity

Keywords

  • Breath analysis
  • Electronic nose
  • Exhaled volatile
  • Inflammation
  • Polysomnography
  • Sleep-disordered breathing

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Pediatrics, Perinatology, and Child Health

Cite this

Exhaled biomarker pattern is altered in children with obstructive sleep apnoea syndrome. / Benedek, Pálma; Lázár, Zsófia; Bikov, András; Kunos, László; Katona, Gábor; Horváth, I.

In: International Journal of Pediatric Otorhinolaryngology, Vol. 77, No. 8, 08.2013, p. 1244-1247.

Research output: Contribution to journalArticle

Benedek, Pálma ; Lázár, Zsófia ; Bikov, András ; Kunos, László ; Katona, Gábor ; Horváth, I. / Exhaled biomarker pattern is altered in children with obstructive sleep apnoea syndrome. In: International Journal of Pediatric Otorhinolaryngology. 2013 ; Vol. 77, No. 8. pp. 1244-1247.
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